Greek translation of a summary of the 2017 update of the consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology

被引：0

作者：

Schoretsanitis, G. ^{[1
]}

Pallis, E. G. ^{[2
]}

Paulzen, M. ^{[3
,4
,5
]}

Unterecker, S. ^{[6
]}

Schwarz, M. ^{[7
]}

Conca, A. ^{[8
]}

Zernig, G. ^{[9
,10
]}

Gruender, G. ^{[11
]}

Haen, E. ^{[12
,13
]}

Baumann, P. ^{[14
]}

Bergemann, N. ^{[15
]}

Domschke, K. ^{[16
]}

Eckermann, G. ^{[17
]}

Egberts, K. ^{[18
]}

Gerlach, M. ^{[18
]}

Greiner, C. ^{[19
]}

Hefner, G. ^{[20
]}

Jaquenoud, E. ^{[21
]}

Laux, G. ^{[22
]}

Messer, T. ^{[23
]}

Mueller, M. J. ^{[24
]}

Riederer, P. ^{[6
]}

Saria, A. ^{[9
]}

Stegmann, B. ^{[12
,13
]}

Steimer, W. ^{[25
]}

Stingl, J. ^{[26
]}

Uhr, M. ^{[27
]}

Ulrich, S. ^{[28
]}

Waschgler, R. ^{[29
]}

Zurek, G. ^{[30
]}

Hiemke, C. ^{[31
,32
]}

机构：

[1] Zucker Hillside Hosp, Northwell Hlth, Glen Oaks, NY USA

[2] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Med, Athens, Greece

[3] Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, Aachen, Germany

[4] JARA Translat Brain Med, Aachen, Germany

[5] Alexianer Hosp Aachen, Aachen, Germany

[6] Univ Hosp Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany

[7] Ludwig Maximilians Univ Munchen, Dept Lab Med, Munich, Germany

[8] Serv Psichiatr Comprensorio Sanit Bolzano, Bolzano, Italy

[9] Med Univ Innsbruck, Dept Psychiat & Psychotherapy, Expt Psychiat Unit, Innsbruck, Austria

[10] Private Practice Psychotherapy & Court Certified, Hall In Tirol, Austria

[11] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Mol Neuroimaging, Mannheim, Germany

[12] Univ Regensburg, Dept Psychiat & Psychotherapy, Clin Pharmacol, Regensburg, Germany

[13] Univ Regensburg, Dept Pharmacol & Toxicol, Regensburg, Germany

[14] Univ Lausanne, Dept Psychiat, Prilly, Switzerland

[15] Kitzberg Hosp, Ctr Psychosomat Med & Psychotherapy, Bad Mergentheim, Germany

[16] Univ Freiburg, Fac Med, Med Ctr, Dept Psychiat & Psychotherapy, Freiburg, Germany

[17] Psychiat Hosp, Kaufbeuren, Germany

[18] Univ Hosp Wurzburg, Ctr Mental Hlth, Dept Child & Adolescent Psychiat Psychosomat & Ps, Wurzburg, Germany

[19] Fed Inst Drugs & Med Devices BfArM, Bonn, Germany

[20] Vitos Klin, Psychiat Hosp, Eichberg, Eltville, Germany

[21] Psychiat Hosp, Brugg, Aargau, Switzerland

[22] Inst Psychol Med, Haag, Germany

[23] Psychiat Hosp, Danuviuskliniken, Pfaffenhofen, Germany

[24] Psychiat Hosp Oberberggrp, Berlin, Germany

[25] Tech Univ Munich, Inst Clin Chem & Pathobiochem, Munich, Germany

[26] Univ Hosp RWTH Aachen, Inst Clin Pharmacol, Aachen, Germany

[27] Max Planck Inst Psychiat, Munich, Germany

[28] Aristo Pharma GmbH, Berlin, Germany

[29] Psychiat Hosp, Feldkirch, Austria

[30] Med Lab Bremen, Bremen, Germany

[31] Univ Med Ctr Mainz, Dept Psychiat & Psychotherapy, Mainz, Germany

[32] Univ Med Ctr Mainz, Inst Clin Chem & Lab Med, Mainz, Germany

来源：

ARCHIVES OF HELLENIC MEDICINE | 2021年 / 38卷 / 06期

关键词：

Antidepressants; Antipsychotics; Mood stabilizers; Psychiatry; Therapeutic drug monitoring; PHARMACOKINETICS; SCHIZOPHRENIA; RISPERIDONE; PSYCHIATRY; TDM;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The quantification and pharmacological interpretation of drug concentrations in blood (serum or plasma) is widely known as therapeutic drug monitoring (TDM). In clinical practice, TDM is an established precision tool that provides the fundamental prerequisites for personalized treatment. Specifically, in neurology and psychiatry, TDM can be used as part of the process of prescription of medications in specific patient subgroups, including children and adolescents, pregnant women, elderly patients, patients with intellectual disabilities, patients with substance abuse disorders, individuals with pharmacokinetic idiosyncrasies and forensic patients. Clinicians may consider TDM in the case of lack of clinical response to therapeutic doses of medication, assessment of drug adherence, tolerability and drug-drug interactions. This is the Greek translation of a short summary of the updated consensus guidelines compiled by the TDM task force of the Arbeitsgemeinschaft fur Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP). It includes therapeutic reference ranges, laboratory alert levels, recommendation levels for prescribing TDM for dosage optimization without specific indications, conversion factors, factors for calculation of dosage-related drug concentrations and metabolite-to-parent ratios.

引用

页码：817 / 832

页数：16

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