GLUT1/3/4 as novel biomarkers for the prognosis of human breast cancer

被引:21
作者
Zeng, Kai [1 ]
Ju, Gaoda [1 ]
Wang, Hao [2 ]
Huang, Jiangsheng [1 ]
机构
[1] Cent South Univ, Xiangya Hosp 2, Dept Minimally Invas Surg, 139 Remin Middle Rd, Changsha 410000, Peoples R China
[2] Nanjing Univ Chinese Med, Yancheng TCM Hosp, Yancheng 224002, Peoples R China
关键词
Bioinformatics; biomarker; breast cancer (BC); glucose transporter (GLUT); relapse-free survival (RFS); GLUCOSE-TRANSPORTER ISOFORMS; GENE-EXPRESSION; HISTOLOGIC TYPE; GLUT-1; OVEREXPRESSION; CARCINOMAS; GLUCOSE-TRANSPORTER-1; METABOLISM; PROTEINS; PATHWAY;
D O I
10.21037/tcr.2020.03.50
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Anomalous expression of glucose transporters (GLUTs) has been observed in a variety of tumor tissues. Although GLUT factors have been shown to have prognostic value for some cancer types, detailed bioinformatics investigation of the factors contributing to the prognostic prediction for patients with breast cancer (BC) has not yet been performed. Methods: In this study, we examined the transcription levels of GLUT1, GLUT3, and GLUT4 and their associations with prognostic clinical data in patients with BC from the ONCOMINE database, using gene expression profiling interactive analysis (GEPIA), Kaplan-Meier (KM) plotter, and cBioPortal online tools. Results: The transcription level of GLUT1 was significantly higher in the BC samples than in the normal tissues, whereas the levels of GLUT3 and GLUT4 were lower in the BC samples. The expression levels of GLUT1 and GLUT3 were associated with the cancer clinical stage. Consistently, survival analysis demonstrated that a high expression level of GLUT1 was associated with low relapse-free survival (RFS) in patients with BC, whereas high GLUT3 and GLUT4 levels predicted a longer RFS in these patients. Conclusions: Overall, these results suggest GLUT1 as an effective target of precision therapy, while GLUT3/4 are novel biomarkers for the prognosis of patients with BC.
引用
收藏
页码:2363 / 2377
页数:15
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