Brain-derived gangliosides suppress the chronic relapsing-remitting experimental autoimmune encephalomyelitis in NOD mice induced with myelin oligodendrocyte glycoprotein peptide

被引：10
作者：
Sekiguchi, Y
Ichikawa, M
Inoue, A
Itoh, M
Koh, CS
机构：
[1] Shinshu Univ, Sch Med, Dept Med Neurol, Matsumoto, Nagano 3908621, Japan
[2] Shinshu Univ, Sch Med, Dept Pediat, Matsumoto, Nagano 3908621, Japan
[3] Nagoya Univ, Sch Med, Dept Pathol 1, Showa Ku, Nagoya, Aichi 4668550, Japan
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 116卷 / 02期
关键词：
chronic relapsing-remitting experimental autoimmune encephalomyelitis; gangliosides; myelin oligodendrocyte glycoprotein; multiple sclerosis;
D O I：
10.1016/S0165-5728(01)00298-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chronic relapsing-remitting experimental autoimmune encephalomyelitis (CREAE) induced with myelin oligodendrocyte glycoprotein peptides 35-55 (MOG(35-55)) in NOD mice was successfully treated with brain-derived gangliosides (GA). The GA treatment suppressed the development and severity of CREAE, both clinically and histologically. Spleen cells from the GA-treated mice displayed markedly inhibited levels of MOG(35-55) specific proliferation and interferon-gamma production. Delayed-type hypersensitivity reactions to MOG(35-55) were suppressed by the GA treatment. GA modulate various T cell effector functions in CREAE and may be an effective therapeutic agent for autoimmune demyelinating diseases such as multiple sclerosis. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：196 / 205
页数：10
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