Brain-derived gangliosides suppress the chronic relapsing-remitting experimental autoimmune encephalomyelitis in NOD mice induced with myelin oligodendrocyte glycoprotein peptide

被引：10
|
作者：
Sekiguchi, Y
Ichikawa, M
Inoue, A
Itoh, M
Koh, CS
机构：
[1] Shinshu Univ, Sch Med, Dept Med Neurol, Matsumoto, Nagano 3908621, Japan
[2] Shinshu Univ, Sch Med, Dept Pediat, Matsumoto, Nagano 3908621, Japan
[3] Nagoya Univ, Sch Med, Dept Pathol 1, Showa Ku, Nagoya, Aichi 4668550, Japan
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 116卷 / 02期
关键词：
chronic relapsing-remitting experimental autoimmune encephalomyelitis; gangliosides; myelin oligodendrocyte glycoprotein; multiple sclerosis;
D O I：
10.1016/S0165-5728(01)00298-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chronic relapsing-remitting experimental autoimmune encephalomyelitis (CREAE) induced with myelin oligodendrocyte glycoprotein peptides 35-55 (MOG(35-55)) in NOD mice was successfully treated with brain-derived gangliosides (GA). The GA treatment suppressed the development and severity of CREAE, both clinically and histologically. Spleen cells from the GA-treated mice displayed markedly inhibited levels of MOG(35-55) specific proliferation and interferon-gamma production. Delayed-type hypersensitivity reactions to MOG(35-55) were suppressed by the GA treatment. GA modulate various T cell effector functions in CREAE and may be an effective therapeutic agent for autoimmune demyelinating diseases such as multiple sclerosis. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：196 / 205
页数：10
相关论文
共 50 条
  • [21] Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice
    Rich, C
    Link, JM
    Zamora, A
    Jacobsen, H
    Meza-Romero, R
    Offner, H
    Jones, R
    Burrows, GG
    Fugger, L
    Vandenbark, AA
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (05) : 1251 - 1261
  • [22] Hydroxytyrosol improves clinical and neuropathological signs of both relapsing-remitting and chronic non-remitting experimental autoimmune encephalomyelitis
    Mansilla, Maria Jose
    Costa, Carme
    Castillo, Mireia
    Geerlings, A.
    Xaus, Jordi
    Boza, J.
    Comabella, Manuel
    Montalban, Xavier
    Espejo, Carmen
    MULTIPLE SCLEROSIS, 2008, 14 : S84 - S84
  • [23] Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice
    Malipiero, U
    Frei, K
    Spanaus, KS
    Agresti, C
    Lassmann, H
    Hahne, M
    Tschopp, J
    Eugster, HP
    Fontana, A
    EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (12) : 3151 - 3160
  • [24] IDENTIFICATION OF A COMMON IDIOTYPE ON MYELIN OLIGODENDROCYTE GLYCOPROTEIN-SPECIFIC AUTOANTIBODIES IN CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
    GUNN, C
    SUCKLING, AJ
    LININGTON, C
    JOURNAL OF NEUROIMMUNOLOGY, 1989, 23 (02) : 101 - 108
  • [25] IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    Eugster, HP
    Frei, K
    Kopf, M
    Lassmann, H
    Fontana, A
    EUROPEAN JOURNAL OF IMMUNOLOGY, 1998, 28 (07) : 2178 - 2187
  • [26] Mice overexpressing bcl-2 in their neurons are resistant to myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE)
    Offen, D
    Kaye, JF
    Bernard, O
    Merims, D
    Coire, CI
    Panet, H
    Melamed, E
    Ben-Nun, A
    JOURNAL OF MOLECULAR NEUROSCIENCE, 2000, 15 (03) : 167 - 176
  • [27] Mice Devoid of Tau Have Increased Susceptibility to Neuronal Damage in Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis
    Weinger, Jason G.
    Davies, Peter
    Acker, Christopher M.
    Brosnan, Celia F.
    Tsiperson, Vladislav
    Bayewitz, Ashrei
    Shafit-Zagardo, Bridget
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2012, 71 (05): : 422 - 433
  • [28] Mice overexpressing Bcl-2 in their neurons are resistant to myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE)
    Daniel Offen
    Joel F. Kaye
    Ora Bernard
    Doron Merims
    Clare I. Coire
    Hana Panet
    Eldad Melamed
    A. Ben-Nun
    Journal of Molecular Neuroscience, 2000, 15 : 167 - 176
  • [29] Gender does not influence the susceptibility of C57BL/6 mice to develop chronic experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein
    Okuda, Y
    Okuda, M
    Bernard, CCA
    IMMUNOLOGY LETTERS, 2002, 81 (01) : 25 - 29
  • [30] Protective Effect of PBCA Nanoparticles Loaded with Thymulin Against the Relapsing-Remitting Form of Experimental Autoimmune Encephalomyelitis in Mice
    Lunin, Sergey M.
    Khrenov, Maxim O.
    Glushkova, Olga V.
    Parfenyuk, Svetlana B.
    Novoselova, Tatyana V.
    Novoselova, Elena G.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (21)
12345