Relation of dietary inorganic arsenic to serum matrix metalloproteinase-9 (MMP-9) at different threshold concentrations of tap water arsenic

被引:12
|
作者
Kurzius-Spencer, Margaret [1 ,2 ]
Harris, Robin B. [2 ,3 ]
Hartz, Vern [3 ]
Roberge, Jason [4 ]
Hsu, Chiu-Hsieh [2 ,3 ]
O'Rourke, Mary Kay [2 ]
Burgess, Jefferey L. [2 ]
机构
[1] Univ Arizona, Coll Med, Dept Pediat, 1501 N Campbell Ave, Tucson, AZ 85724 USA
[2] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Tucson, AZ 85724 USA
[3] Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA
[4] Carolinas Healthcare Syst, Dickson Adv Analyt Grp, Charlotte, NC USA
关键词
MMP-9; arsenic; dietary exposure; aggregate exposure; biomarker of toxicity; CORONARY-ARTERY-DISEASE; DRINKING-WATER; IN-UTERO; CARDIOVASCULAR-DISEASE; CANCER-MORTALITY; LUNG-FUNCTION; WEST-BENGAL; PROSPECTIVE COHORT; RICE CONSUMPTION; TISSUE INHIBITOR;
D O I
10.1038/jes.2014.92
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Arsenic (As) exposure is associated with cancer, lung and cardiovascular disease, yet the mechanisms involved are not clearly understood. Elevated matrix metalloproteinase-9 (MMP-9) levels are also associated with these diseases, as well as with exposure to water As. Our objective was to evaluate the effects of dietary components of inorganic As (iAs) intake on serum MMP-9 concentration at differing levels of tap water As. In a cross-sectional study of 214 adults, dietary iAs intake was estimated from 24-h dietary recall interviews using published iAs residue data; drinking and cooking water As intake from water samples and consumption data. Aggregate iAs intake (food plus water) was associated with elevated serum MMP-9 in mixed model regression, with and without adjustment for covariates. In models stratified by tap water As, aggregate intake was a significant positive predictor of serum MMP-9 in subjects exposed to water As <= 10 mu g/l. Inorganic As from food alone was associated with serum MMP-9 in subjects exposed to tap water As <= 3 mu g/l. Exposure to iAs from food and water combined, in areas where tap water As concentration is <= 10 mu g/l, may contribute to As-induced changes in a biomarker associated with toxicity.
引用
收藏
页码:445 / 451
页数:7
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