Efficient palladium-catalyzed Suzuki C-C coupling of novel urea/thiourea-based quinazolines

被引：5
作者：
Patel, Amit B. [1 ]
Chikhalia, Kishor H. [2 ]
Kumari, Premlata [1 ]
机构：
[1] SV Natl Inst Technol, Dept Appl Chem, Surat 395007, India
[2] Gujarat Univ, Sch Sci, Dept Chem, Ahmadabad 380009, Gujarat, India
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2015年 / 41卷 / 05期
关键词：
Quinazoline; Suzuki coupling; Urea; Thiourea; PHARMACOLOGICAL EVALUATION; MIYAURA; ARYL; ANTICONVULSANT; DERIVATIVES; CHEMISTRY; GREEN; UREA;
D O I：
10.1007/s11164-013-1377-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two series of novel urea and thiourea-based quinazoline derivatives (7a-g/8a-g) have been synthesized by Suzuki C-C coupling between the C-2 position of quinazoline and a phenyl ring then condensation with N-phenyl isocyanates/isothiocyanates with good overall yields in a short reaction time. All the synthesized compounds were well characterized by IR, NMR, and elemental analysis. Synthesis of these 1-phenyl-3-(4-(4-(m-tolyloxy)quinazolin-2-yl)phenyl)urea/thiourea derivatives was conveniently achieved in only three steps, starting from 2,4-dichloroquinazoline.
引用
收藏
页码：2665 / 2674
页数：10
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