A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives

被引：9
|
作者：
Yu, Wensheng [1 ]
Bulger, Paul G. [2 ]
Maloney, Kevin M. [2 ]
机构：
[1] Merck Res Labs, Discovery Chem, 126 E Lincoln Ave, Rahway, NJ 07065 USA
[2] Merck Res Labs, Proc Chem, 126 E Lincoln Ave, Rahway, NJ 07065 USA
来源：
GREEN CHEMISTRY | 2016年 / 18卷 / 18期
关键词：
INHIBITORS; POTENT;
D O I：
10.1039/c6gc01125j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient and green method has been developed for the rapid preparation of highly functionalized isoxazolopyridin-3-amine derivatives in excellent yields. This process has a broad substrate scope, is operationally simple, and generally requires no chromatographic purification. In addition, the process is scalable and significantly greener than current alternatives with a PMI of 18 and water as the reaction solvent.
引用
收藏
页码：4941 / 4946
页数：6
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