The power of chemotherapeutic engineering Arresting cell cycle and suppressing senescence to protect from mitotic inhibitors

被引：18

作者：

Blagosklonny, Mikhail V. ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY 14263 USA

来源：

CELL CYCLE | 2011年 / 10卷 / 14期

关键词：

cellular senescence; rapamycin; arrest; apoptosis; p53; p21; DNA-DAMAGING AGENTS; P53; MTOR; ACTIVATION; GROWTH; DRUGS; PROLIFERATION; QUIESCENCE; MECHANISM; LEADS;

D O I：

10.4161/cc.10.14.16819

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Suppose one drug causes lethal mitotic arrest, another treatment causes irreversible senescence and a third drug inhibits cellular mass growth. Could cells treated with a combination of all three agents magically emerge alive and proliferating? The result of this experiment is presented here. By knowing the mechanisms of cell cycle arrest, death and senescence, we can design 'rainbow combinations' that obediently kill or spare desired cells. Knowledge is power.

引用

页码：2295 / 2298

页数：4

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