The power of chemotherapeutic engineering Arresting cell cycle and suppressing senescence to protect from mitotic inhibitors

被引：18

作者：

Blagosklonny, Mikhail V. ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY 14263 USA

来源：

CELL CYCLE | 2011年 / 10卷 / 14期

关键词：

cellular senescence; rapamycin; arrest; apoptosis; p53; p21; DNA-DAMAGING AGENTS; P53; MTOR; ACTIVATION; GROWTH; DRUGS; PROLIFERATION; QUIESCENCE; MECHANISM; LEADS;

D O I：

10.4161/cc.10.14.16819

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Suppose one drug causes lethal mitotic arrest, another treatment causes irreversible senescence and a third drug inhibits cellular mass growth. Could cells treated with a combination of all three agents magically emerge alive and proliferating? The result of this experiment is presented here. By knowing the mechanisms of cell cycle arrest, death and senescence, we can design 'rainbow combinations' that obediently kill or spare desired cells. Knowledge is power.

引用

页码：2295 / 2298

页数：4

共 53 条

[41] DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
Leontieva, Olga V.
Blagosklonny, Mikhail V.
[J]. AGING-US, 2010, 2 (12): : 924 - U55
[42] Weak p53 permits senescence during cell cycle arrest
Leontieva, Olga V.
Gudkov, Andrei V.
Blagosklonny, Mikhail V.
[J]. CELL CYCLE, 2010, 9 (21) : 4323 - 4327
[43] Microtubule Active Agents: Beyond the Taxane Frontier
Morris, Patrick G.
Fornier, Monica N.
[J]. CLINICAL CANCER RESEARCH, 2008, 14 (22) : 7167 - 7172
[44] Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance
Perez, Edith A.
[J]. MOLECULAR CANCER THERAPEUTICS, 2009, 8 (08) : 2086 - 2095
[45] Rao B, 2010, ONCOTARGET, V1, P639
[46] Novel agents that target tublin and related elements
Rowinsky, Eric K.
Calvo, Emiliano
[J]. SEMINARS IN ONCOLOGY, 2006, 33 (04) : 421 - 435
[47] Growing roles for the mTOR pathway
Sarbassov, DD
Ali, SM
Sabatini, DM
[J]. CURRENT OPINION IN CELL BIOLOGY, 2005, 17 (06) : 596 - 603
[48] TOR, a central controller of cell growth
Schmelzle, T
Hall, MN
[J]. CELL, 2000, 103 (02) : 253 - 262
[49] Steelman LS, 2011, ONCOTARGET, V2, P109
[50] A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
Sur, Surojit
Pagliarini, Raymond
Bunz, Fred
Rago, Carlo
Diaz, Luis A., Jr.
Kinzler, Kenneth W.
Vogelstein, Bert
Papadopoulos, Nickolas
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (10) : 3964 - 3969

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