Improved solvent-free Dakin oxidation protocol

被引：23

作者：

da Silva, Emerson Teixeira ^{[2
,3
]}

Camara, Celso Amorim ^{[4
]}

Antunes, O. A. C. ^{[2
,3
]}

Barreiro, Eliezer J. ^{[1
]}

Fraga, Carlos A. M. ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Fac Pharm, Lab Avaliacao Sintese Subst Bioactiv, BR-21941 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Inst Chem, BR-21941 Rio De Janeiro, Brazil

[3] Nortec Quim, Duque de Caxias, Brazil

[4] Rural Univ Fed Pernambuco, Dept Chem, Recife, PE, Brazil

来源：

SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 05期

关键词：

Dakin reaction; mCPBA; solvent-free; synthesis of phenols;

D O I：

10.1080/00397910701820673

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A solvent-free Dakin reaction with mCPBA was accomplished with various aromatic aldehydes, resulting in an easy and improved methodology for the preparation of corresponding phenols. 3,4-Methylenedioxyphenol, 3,4-dimethoxyphenol, 4-methoxyphenol, 4-chlorophenol, and other functionalized phenols were obtained in high yields from the corresponding aromatic aldehydes in a few minutes. This new methodology represents an efficient alternative for this important synthetic conversion.

引用

页码：784 / 788

页数：5

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