Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?

被引：11

作者：

Tejera Segura, Beatriz ^{[1
]}

Altabas Gonzalez, Irene ^{[2
,3
]}

Rua-Figueroa, Inigo ^{[4
]}

Perez Veiga, Natalia ^{[3
]}

Del Campo Perez, Victor ^{[5
]}

Olive-Marques, Alejandro ^{[6
]}

Galindo, Maria ^{[7
]}

Calvo, Jaime ^{[8
]}

Gabriel Ovalles-Bonilla, Juan ^{[9
]}

Fernandez-Nebro, Antonio ^{[10
,11
,12
]}

Menor-Almagro, Raul ^{[13
]}

Tomero, Eva ^{[14
]}

del Val del Amo, Natividad ^{[15
]}

Uriarte Isacelaya, Esther ^{[16
]}

Manuel Martinez-Taboada, Victor ^{[17
]}

Andreu, Jose L. ^{[18
]}

Boteanu, Alina ^{[19
]}

Narvaez, Javier ^{[20
]}

Movasat, Atusa ^{[21
]}

Montilla, Carlos ^{[22
]}

Senabre Gallego, Jose Miguel ^{[23
]}

Hernandez-Cruz, Blanca ^{[24
]}

Andres, Mariano ^{[25
]}

Salgado, Eva ^{[26
]}

Freire, Mercedes ^{[27
]}

Machin Garcia, Sergio ^{[1
]}

Moriano, Clara ^{[28
]}

Exposito, Lorena ^{[29
]}

Perez Velasquez, Clara ^{[30
]}

Velloso-Feijoo, M. L. ^{[31
]}

Paula Cacheda, Ana ^{[32
]}

Lozano-Rivas, Nuria ^{[33
]}

Bonilla, Gema ^{[34
]}

Arevalo, Marta ^{[35
]}

Jimenez, Inmaculada ^{[36
]}

Quevedo-Vila, Victor ^{[37
]}

Manero-Ruiz, Francisco J. ^{[38
]}

de la Pena Lefebvre, Paloma Garcia ^{[39
]}

Ramon Vazquez-Rodriguez, Tomas ^{[40
]}

Ibanez-Rua, Jesus ^{[41
]}

Cobo-Ibanez, Tatiana ^{[42
]}

Maria Pego-Reigosa, Jose ^{[2
,3
]}

机构：

[1] Hosp Univ Insular Gran Canaria, Rheumatol Dept, Islas, Canarias, Spain

[2] Complejo Hosp Univ Vigo, Rheumatol Dept, Vigo, Galicia, Spain

[3] Galicia Sur Hlth Res Inst IIS Galicia Sur, Rheumatol & Immunomediated Dis Res Grp IRIDIS, Vigo, Spain

[4] Hosp Univ Gran Canaria Dr Negrin, Rheumatol Dept, Las Palmas Gran Canaria, Islas Canarias, Spain

[5] Vigo Univ, Dept Stat & OR, Vigo, Spain

[6] Germans Trias & Pujol Univ Hosp, Rheumatol Dept, Badalona, Cataluna, Spain

[7] 12 Octubre Univ Hosp, Rheumatol Dept, Madrid, Spain

[8] Hosp Araba, Rheumatol Dept, Araba, Spain

[9] Hosp Gregorio Maranon, Rheumatol Dept, Madrid, Spain

[10] Inst Invest Biomed Malaga IBIMA, Malaga, Spain

[11] Hosp Reg Univ Malaga, Rheumatol Dept, Malaga, Spain

[12] Univ Malaga, Dept Med, Malaga, Spain

[13] Hosp Jerez, Rheumatol Dept, Jerez de la Frontera, Spain

[14] Hosp Univ la Princesa, Rheumatol Dept, Madrid, Spain

[15] Navarra Hosp, Rheumatol Dept, Pamplona, Spain

[16] Hosp Univ Donostia, Rheumatol Dept, San Sebastian, Pais Vasco, Spain

[17] Hosp Marques de Valdecilla, Rheumatol Dept, Santander, Spain

[18] Puerta Hierro Majadahonda Hosp, Rheumatol Dept, Madrid, Spain

[19] Hosp Ramon & Cajal, Rheumatol Dept, Madrid, Spain

[20] Hosp Bellvitge Princeps Espanya, Rheumatol Dept, Lhospitalet De Llobregat, Cataluna, Spain

[21] Hosp Univ Principe de Asturias, Rheumatol Dept, Madrid, Spain

[22] Salamanca Clin Univ Hosp, Rheumatol Dept, Salamanca, Spain

[23] Hosp Marina Baixa, Rheumatol Dept, Alicante, Spain

[24] Virgen Macarena Hosp, Rheumatol Dept, Seville, Spain

[25] Hosp Gen Univ Alicante, Rheumatol Dept, Alicante, Spain

[26] Hosp Univ Orense, Rheumatol Dept, Orense, Spain

[27] Hosp Juan Canalejo La Coruna, Rheumatol Dept, La Coruna, Galicia, Spain

[28] Hosp Univ Leon, Rheumatol Dept, Leon, Spain

[29] Hosp Univ Canarias, Rheumatol Dept, Tenerife, Spain

[30] Hosp Univ Basurto, Rheumatol Dept, Pais Vasco, Spain

[31] Hosp Univ Valme, Rheumatol Dept, Seville, Spain

[32] Hosp Son Llatzer, Rheumatol Dept, Mallorca, Islas Baleares, Spain

[33] Hosp Univ Virgen de la Arrixaca, Rheumatol Dept, Murcia, Spain

[34] La Paz Univ Hosp, Rheumatol Dept, Madrid, Spain

[35] Consorci Sanitari Parc Tauli, Rheumatol Dept, Sabadell, Cataluna, Spain

[36] Hosp Clin San Cecilio, Rheumatol Dept, Granada, Spain

[37] Hosp Monforte, Rheumatol Dept, Monforte, Spain

[38] Hosp Univ Miguel Servet, Rheumatol Dept, Zaragoza, Spain

[39] Hosp Univ HM Sanchinarro, Rheumatol Dept, Madrid, Spain

[40] Hosp Univ Lugo, Rheumatol Dept, Lugo, Spain

[41] Clin POVISA, Rheumatol Unit, Vigo, Spain

[42] Hosp Univ Infanta Sofia, Rheumatol Dept, Madrid, Spain

来源：

RHEUMATOLOGY | 2021年 / 60卷 / 11期

关键词：

systemic lupus erythematosus; gastrointestinal disease; damage; INFLAMMATORY-BOWEL-DISEASE; CELIAC-DISEASE; ORGAN DAMAGE; CLASSIFICATION; ASSOCIATION; INVOLVEMENT; CRITERIA; COLLEGE; INDEX; RISK;

D O I：

10.1093/rheumatology/keab401

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. SLE can affect any part of the gastrointestinal (GI) tract. GI symptoms are reported to occur in >50% of SLE patients. To describe the GI manifestations of SLE in the RELESSER (Registry of SLE Patients of the Spanish Society of Rheumatology) cohort and to determine whether these are associated with a more severe disease, damage accrual and a worse prognosis. Methods. We conducted a nationwide, retrospective, multicentre, cross-sectional cohort study of 3658 SLE patients who fulfil >= 4 ACR-97 criteria. Data on demographics, disease characteristics, activity (SLEDAI-2K or BILAG), damage (SLICC/ACR/DI) and therapies were collected. Demographic and clinical characteristics were compared between lupus patients with and without GI damage to establish whether GI damage is associated with a more severe disease. Results. From 3654 lupus patients, 3.7% developed GI damage. Patients in this group (group 1) were older, they had longer disease duration, and were more likely to have vasculitis, renal disease and serositis than patients without GI damage (group 2). Hospitalizations and mortality were significantly higher in group 1. Patients in group 1 had higher modified SDI (SLICC Damage Index). The presence of oral ulcers reduced the risk of developing damage in 33% of patients. Conclusion. Having GI damage is associated with a worse prognosis. Patients on a high dose of glucocorticoids are at higher risk of developing GI damage which reinforces the strategy of minimizing glucocorticoids. Oral ulcers appear to decrease the risk of GI damage.

引用

页码：5329 / 5336

页数：8

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