Synthesis of alkaloid natural products using solid-supported reagents and scavengers

被引：24
作者：
Baxendale, IR [1 ]
Ley, SV [1 ]
机构：
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
来源：
CURRENT ORGANIC CHEMISTRY | 2005年 / 9卷 / 15期
关键词：
D O I：
10.2174/138527205774370513
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Supported reagents and scavengers have become key tools for the synthesis of biologically important molecular entities. The complexity of the target molecules attainable and the synthetic flexibility afforded by these systems now rivals any solution phase approach whilst offering the added advantage of rapid purification and work-up. This short review highlights the application of these immobilized reagents to the preparation of alkaloid natural products.
引用
收藏
页码：1521 / 1534
页数：14
相关论文
共 130 条
[1]   NICOTINE-INDUCED PROTECTION OF CULTURED CORTICAL-NEURONS AGAINST N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED GLUTAMATE CYTOTOXICITY [J].
AKAIKE, A ;
TAMURA, Y ;
YOKOTA, T ;
SHIMOHAMA, S ;
KIMURA, J .
BRAIN RESEARCH, 1994, 644 (02) :181-187
[2]   RECENT DEVELOPMENTS IN THE APPLICATION OF FUNCTIONALIZED POLYMERS IN ORGANIC-SYNTHESIS [J].
AKELAH, A ;
SHERRINGTON, DC .
POLYMER, 1983, 24 (11) :1369-1386
[3]   APPLICATION OF FUNCTIONALIZED POLYMERS IN ORGANIC-SYNTHESIS [J].
AKELAH, A ;
SHERRINGTON, DC .
CHEMICAL REVIEWS, 1981, 81 (06) :557-587
[4]   Enantioselective approach to 7-azabicyclo[2.2.1]heptane ring systems using D-(-)-quinic acid as the chiral educt: Application to the formal synthesis of (+)-epibatidine [J].
Albertini, E ;
Barco, A ;
Benetti, S ;
DeRisi, C ;
Pollini, GP ;
Zanirato, V .
TETRAHEDRON LETTERS, 1997, 38 (04) :681-684
[5]   TOTAL SYNTHESIS OF (+/-)-EPIBATIDINE [J].
ALBERTINI, E ;
BARCO, A ;
BENETTI, S ;
DERISI, C ;
POLLINI, GP ;
ROMAGNOLI, R ;
ZANIRATO, V .
TETRAHEDRON LETTERS, 1994, 35 (49) :9297-9300
[6]   CYTOTOXICITY OF HYMENOCALLIS-EXPANSA ALKALOIDS [J].
ANTOUN, MD ;
MENDOZA, NT ;
RIOS, YR ;
PROCTOR, GR ;
WICKRAMARATNE, DBM ;
PEZZUTO, JM ;
KINGHORN, AD .
JOURNAL OF NATURAL PRODUCTS, 1993, 56 (08) :1423-1425
[7]   Total synthesis of (-)-epibatidine using an asymmetric Diels-Alder reaction with a chiral N-acylnitroso dienophile [J].
Aoyagi, S ;
Tanaka, R ;
Naruse, M ;
Kibayashi, C .
JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (23) :8397-8406
[8]   POTENTIAL TREATMENT OF ALZHEIMER-DISEASE USING CHOLINERGIC CHANNEL ACTIVATORS (CHCAS) WITH COGNITIVE ENHANCEMENT, ANXIOLYTIC-LIKE, AND CYTOPROTECTIVE PROPERTIES [J].
ARNERIC, SP ;
SULLIVAN, JP ;
DECKER, MW ;
BRIONI, JD ;
BANNON, AW ;
BRIGGS, CA ;
DONNELLYROBERTS, D ;
RADEK, RJ ;
MARSH, KC ;
KYNCL, J ;
WILLIAMS, M ;
BUCCAFUSCO, JJ .
ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 1995, 9 :50-61
[9]  
Avenoza A, 1998, SYNTHESIS-STUTTGART, P1335
[10]  
BALANDRIN MF, 1993, ACS SYM SER, V534, P2
12345678910