Expression of ligands for NK receptors in human prostasomes: functional implications on NK cell activation

被引：0

作者：

Tarazona, R. ^{[1
]}

Delgado, E. ^{[2
]}

Guarnizo, M. C. ^{[2
]}

Gonzalez, M. R. ^{[1
]}

Morgado, S. ^{[1
]}

Correa, Sanchez B. ^{[1
]}

Gordillo, J. J. ^{[1
]}

Merchan, F. ^{[3
]}

De Julian, J. ^{[2
]}

Casado, J. G. ^{[1
]}

机构：

[1] Univ Extremadura, Immunol Unit, Caceres, Spain

[2] Norba, Ginecol & Reprod, Caceres, Spain

[3] Univ Extremadura, Dept Biochem Mol Biol & Genet, Caceres, Spain

来源：

2ND EUROPEAN CONGRESS OF IMMUNOLOGY (ECI) | 2009年

关键词：

EXTRACELLULAR ORGANELLES PROSTASOMES; HUMAN SEMINAL PLASMA; SEMEN;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The female reproductive tract adapts to allow the development of the fetus and several mechanisms are required to protect the fetus from the material immune response. Recent reports have involved ulerine NK cell activity in implantation failures and abortions. Here, we have analysed the role of prostasumes in the regulation of NK cell activity. prostasomes are small vesicles secreted byt he prostatic gland that contribute to sperm protection within the female reproductive tract because their immunosuppresive properties. The phenotypical analysis performed by flow cytometry revealed that prostasomes expressed high levels of CD48 and CD86 molecules but did not express MICAIB, CD80, CD112, or CD155. In conclusion, the expression of ligands for NK receptors in prostasomes may have functional relevance in the modulation of NK cell triggering.

引用

页码：555 / +

页数：2

共 17 条

[1] Isolation of human cationic antimicrobial protein-18 from seminal plasma and its association with prostasomes [J].