Effect of anterior chamber depth on the choice of intraocular lens calculation formula

Purpose To investigate the effect of anterior chamber depth (ACD) on the refractive outcomes of the SRK/T, Holladay 1, Hoffer Q and Haigis formulae in short, normal, long and extremely long eyes. Methods This retrospective study involved patients who had uncomplicated cataract surgery. Preoperative axial length (AL) was divided into four subgroups: short (< 22.00 mm), normal (22.00-24.49 mm), long (24.50-25.99 mm), extremely long (>= 26.00 mm). Preoperative ACD was divided into three subgroups: < 2.5, 2.50 +/- 3.49, and >= 3.5 mm. Median absolute errors (MedAEs) predicted by the SRK/T, Holladay 1, Hoffer Q and Haigis formulae were compared with the Friedman test. Post-hoc analysis involved the Wilcoxon signed rank test with a Bonferroni adjustment. Correlations between ACD and the predictive refractive errors of the four formulas were analyzed. Results In short eyes with an ACD < 2.5 mm, the Haigis formula revealed the highest MedAE. The difference in MedAE with the Hoffer Q formula (which had the lowest MedAE) was statistically significant (P = 0.002). In normal eyes, the Haigis formula significantly differed from the Holladay 1 (P = 0.002) and Hoffer Q (P = 0.005) formulae in the ACD < 2.5 mm group. In long eyes and extremely long eyes with an ACD >= 3.5 mm, the differences in MedAEs were statistically significant (P = 0.018, P = 0.001, respectively) and the Haigis formula had the lowest MedAEs in both subgroups (0.29 D, 0.30 D, respectively). In the total of 1,123 eyes, refractive errors predicted by the Haigis formula showed a significant negative correlation with the ACD (R-2 = 0.002, P = 0.047). Conclusions The Hoffer Q formula is preferred over other formulae in short eyes with an ACD shallower than 2.5 mm. In short and normal eyes with an ACD < 2.5 mm the Haigis formula might underestimate ELP. The Haigis formula is the preferred choice in eyes with an AL >= 24.5 mm and an ACD >= 3.5 mm.