Structural evaluation in inherited retinal diseases

被引：21
作者：
Varela, Malena Daich [1 ,2 ]
Esener, Burak [3 ]
Hashem, Shaima A. [1 ,2 ]
de Guimaraes, Thales Antonio Cabral [1 ,2 ]
Georgiou, Michalis [1 ,2 ]
Michaelides, Michel [1 ,2 ]
机构：
[1] Moorfields Eye Hosp, City Rd Campus, London, England
[2] UCL, UCL Inst Ophthalmol, London, England
[3] Inonu Univ, Dept Ophthalmol, Sch Med, Malatya, Turkey
来源：
BRITISH JOURNAL OF OPHTHALMOLOGY | 2021年 / 105卷 / 12期
基金：
英国惠康基金;
关键词：
imaging; genetics; clinical trial; retina; dystrophy; OPTICAL COHERENCE TOMOGRAPHY; NEAR-INFRARED AUTOFLUORESCENCE; CONE DENSITY-MEASUREMENTS; VESSEL OXYGEN-SATURATION; FUNDUS AUTOFLUORESCENCE; RETINITIS-PIGMENTOSA; STARGARDT DISEASE; IN-VIVO; VISUAL FUNCTION; ATROPHY SECONDARY;
D O I：
10.1136/bjophthalmol-2021-319228
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Ophthalmic genetics is a field that has been rapidly evolving over the last decade, mainly due to the flourishing of translational medicine for inherited retinal diseases (IRD). In this review, we will address the different methods by which retinal structure can be objectively and accurately assessed in IRD. We review standard-of-care imaging for these patients: colour fundus photography, fundus autofluorescence imaging and optical coherence tomography (OCT), as well as higher-resolution and/or newer technologies including OCT angiography, adaptive optics imaging, fundus imaging using a range of wavelengths, magnetic resonance imaging, laser speckle flowgraphy and retinal oximetry, illustrating their utility using paradigm genotypes with on-going therapeutic efforts/trials.
引用
收藏
页码：1623 / 1631
页数：9
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