Evaluation of the radical scavenging activity of a series of synthetic hydroxychalcones towards the DPPH radical

被引：15
|
作者：
Todorova, Iva T. [1 ]
Batovska, Daniela I. [1 ]
Stamboliyska, Bistra A. [1 ]
Parushev, Stoyan P. [1 ]
机构：
[1] Bulgarian Acad Sci, Ctr Phytochem, Inst Organ Chem, BU-1113 Sofia, Bulgaria
来源：
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2011年 / 76卷 / 04期
关键词：
hydroxychalcones; 4 '-chlorohydroxychalcones; synthesis; radical-scavenging activity; DPPH free radical; ANTIOXIDANT; CHALCONES;
D O I：
10.2298/JSC100517043T
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sixteen hydroxychalcones were synthesized in sufficient purity by the Claisen-Schmidt condensation between appropriate acetophenones and aromatic aldehydes. All the compounds were evaluated for their ability to scavenge the stable free 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. Important structure activity relationships were observed that strongly contribute to the knowledge for the design of DPPH radical scavenging chalcones. Relevant theoretical parameters were computed in an attempt to understand and explain the obtained experimental results.
引用
收藏
页码：491 / 497
页数：7
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