A no-Wnt situation: SFRPs as axon guidance molecules

被引：10
作者：
Drescher, U [1 ]
机构：
[1] Kings Coll London, MRC, Ctr Dev Neurobiol, London SE1 1UL, England
来源：
NATURE NEUROSCIENCE | 2005年 / 8卷 / 10期
关键词：
D O I：
10.1038/nn1005-1281
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
SFRPs are endogenous inhibitors of Wnt signaling. New work shows that, independently of its interaction with Wnts, SFRP1 can act as a repulsive guidance molecule for retinal axons on their way to the tectum, signaling through the receptor Fz2.
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收藏
页码：1281 / 1282
页数：3
相关论文
共 15 条
  • [1] Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP
    Ahumada, A
    Slusarski, DC
    Liu, XX
    Moon, RT
    Malbon, CC
    Wang, HY
    [J]. SCIENCE, 2002, 298 (5600) : 2006 - 2010
  • [2] Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling
    Bafico, A
    Gazit, A
    Pramila, T
    Finch, PW
    Yaniv, A
    Aaronson, SA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (23) : 16180 - 16187
  • [3] WNTs in the vertebrate nervous system: From patterning to neuronal connectivity
    Ciani, L
    Salinas, PC
    [J]. NATURE REVIEWS NEUROSCIENCE, 2005, 6 (05) : 351 - U17
  • [4] Wnts send axons up and down the spinal cord
    Dickson, BJ
    [J]. NATURE NEUROSCIENCE, 2005, 8 (09) : 1130 - 1132
  • [5] SFRP1 modulates retina cell differentiation through a β-catenin-independent mechanism
    Esteve, P
    Trousse, F
    Rodríguez, J
    Bovolenta, P
    [J]. JOURNAL OF CELL SCIENCE, 2003, 116 (12) : 2471 - 2481
  • [6] HARRIS WA, 1987, DEVELOPMENT, V101, P123
  • [7] Signaling at the growth cone: Ligand-receptor complexes and the control of axon growth and guidance
    Huber, AB
    Kolodkin, AL
    Ginty, DD
    Cloutier, JF
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, 2003, 26 : 509 - 563
  • [8] Secreted antagonists of the Wnt signalling pathway
    Kawano, Y
    Kypta, R
    [J]. JOURNAL OF CELL SCIENCE, 2003, 116 (13) : 2627 - 2634
  • [9] Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth
    Lu, WG
    Yamamoto, V
    Ortega, B
    Baltimore, D
    [J]. CELL, 2004, 119 (01) : 97 - 108
  • [10] Regulation of axial patterning of the retina and its topographic mapping in the brain
    McLaughlin, T
    Hindges, R
    O'Leary, DDM
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 2003, 13 (01) : 57 - 69
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