Functionalized helical fibre bundles of carbon nanotubes as electrochemical sensors for long-term in vivo monitoring of multiple disease biomarkers

被引：301

作者：

Wang, Liyuan ^{[1
,2
]}

Xie, Songlin ^{[1
,2
]}

Wang, Zhiyuan ^{[3
]}

Liu, Fei ^{[4
]}

Yang, Yifan ^{[4
]}

Tang, Chengqiang ^{[1
,2
]}

Wu, Xiaoying ^{[1
,2
]}

Liu, Peng ^{[1
,2
]}

Li, Yongjing ^{[1
,2
]}

Saiyin, Hexige ^{[3
]}

Zheng, Shuang ^{[1
,2
]}

Sun, Xuemei ^{[1
,2
]}

Xu, Fan ^{[4
]}

Yu, Hongbo ^{[3
]}

Peng, Huisheng ^{[1
,2
]}

机构：

[1] Fudan Univ, Dept Macromol Sci, State Key Lab Mol Engn Polymers, Shanghai, Peoples R China

[2] Fudan Univ, Lab Adv Mat, Shanghai, Peoples R China

[3] Fudan Univ, Collaborat Innovat Ctr Brain Sci, Sch Life Sci, Vis Res Lab,State Key Lab Med Neurobiol, Shanghai, Peoples R China

[4] Fudan Univ, Dept Aeronaut & Astronaut, Shanghai, Peoples R China

来源：

NATURE BIOMEDICAL ENGINEERING | 2020年 / 4卷 / 02期

基金：

中国博士后科学基金;

关键词：

MECHANICAL-PROPERTIES; COLLAGEN; DENSITY; FORCES; CANCER; TUMOR;

D O I：

10.1038/s41551-019-0462-8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Mechanical mismatches between implanted electronics and biological tissues can lead to inaccurate readings and long-term tissue damage. Here, we show that functionalized multi-walled carbon nanotubes twisted into helical fibre bundles that mimic the hierarchical structure of muscle can monitor multiple disease biomarkers in vivo. The flexible fibre bundles are injectable, have a low bending stiffness and display ultralow stress under compression. As proof-of-concept evidence of the sensing capabilities of these fibre bundles, we show that the fibre bundles enable the spatially resolved and real-time monitoring of H2O2 when implanted in tumours in mice, and that they can be integrated with a wireless transmission system on an adhesive skin patch to monitor calcium ions and glucose in the venous blood of cats for 28d. The versatility of the helical fibre bundles as chemically functionalized electrochemical sensors makes them suitable for multiple sensing applications in biomedicine and healthcare. Functionalized multi-walled carbon nanotubes twisted into helical fibre bundles that mimic the hierarchical structure of muscle can be used for the long-term monitoring of multiple disease biomarkers in vivo.

引用

页码：159 / 171

页数：13

共 52 条

[31] Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform [J].

Lipani, Luca ;

Dupont, Bertrand G. R. ;

Doungmene, Floriant ;

Marken, Frank ;

Tyrrell, Rex M. ;

Guy, Richard H. ;

Ilie, Adelina .

NATURE NANOTECHNOLOGY, 2018, 13 (06) :504-+

[32]

Liu J, 2015, NAT NANOTECHNOL, V10, P629, DOI [10.1038/nnano.2015.115, 10.1038/NNANO.2015.115]

[33] Understanding the Toxicity of Carbon Nanotubes [J].

Liu, Ying ;

Zhao, Yuliang ;

Sun, Baoyun ;

Chen, Chunying .

ACCOUNTS OF CHEMICAL RESEARCH, 2013, 46 (03) :702-713

[34] Detection of Extracellular H2O2 Released from Human Liver Cancer Cells Based on TiO2 Nanoneedles with Enhanced Electron Transfer of Cytochrome c [J].

Luo, Yongping ;

Liu, Haiqing ;

Rui, Qi ;

Tian, Yang .

ANALYTICAL CHEMISTRY, 2009, 81 (08) :3035-3041

[35] Electronic dura mater for long-term multimodal neural interfaces [J].

Minev, Ivan R. ;

Musienko, Pavel ;

Hirsch, Arthur ;

Barraud, Quentin ;

Wenger, Nikolaus ;

Moraud, Eduardo Martin ;

Gandar, Jerome ;

Capogrosso, Marco ;

Milekovic, Tomislav ;

Asboth, Leonie ;

Torres, Rafael Fajardo ;

Vachicouras, Nicolas ;

Liu, Qihan ;

Pavlova, Natalia ;

Duis, Simone ;

Larmagnac, Alexandre ;

Voeroes, Janos ;

Micera, Silvestro ;

Suo, Zhigang ;

Courtine, Gregoire ;

Lacour, Stephanie P. .

SCIENCE, 2015, 347 (6218) :159-163

[36] Stability analysis of double-walled carbon nanotubes as AFM probes based on a continuum model [J].

Natsuki, Toshiaki ;

Ni, Qing-Qing ;

Endo, Morinobu .

CARBON, 2011, 49 (07) :2532-2537

[37] Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity [J].

Oxley, Thomas J. ;

Opie, Nicholas L. ;

John, Sam E. ;

Rind, Gil S. ;

Ronayne, Stephen M. ;

Wheeler, Tracey L. ;

Judy, Jack W. ;

McDonald, Alan J. ;

Dornom, Anthony ;

Lovell, Timothy J. H. ;

Steward, Christopher ;

Garrett, David J. ;

Moffat, Bradford A. ;

Lui, Elaine H. ;

Yassi, Nawaf ;

Campbell, Bruce C. V. ;

Wong, Yan T. ;

Fox, Kate E. ;

Nurse, Ewan S. ;

Bennett, Iwan E. ;

Bauquier, Sebastien H. ;

Liyanage, Kishan A. ;

van der Nagel, Nicole R. ;

Perucca, Piero ;

Ahnood, Arman ;

Gill, Katherine P. ;

Yan, Bernard ;

Churilov, Leonid ;

French, Christopher R. ;

Desmond, Patricia M. ;

Horne, Malcolm K. ;

Kiers, Lynette ;

Prawer, Steven ;

Davis, Stephen M. ;

Burkitt, Anthony N. ;

Mitchell, Peter J. ;

Grayden, David B. ;

May, Clive N. ;

O'Brien, Terence J. .

NATURE BIOTECHNOLOGY, 2016, 34 (03) :320-+

[38]

Rodenhizer D, 2016, NAT MATER, V15, P227, DOI [10.1038/nmat4482, 10.1038/NMAT4482]

[39] Effect of van der Waals forces on axial buckling of a double-walled carbon nanotube [J].

Ru, CQ .

JOURNAL OF APPLIED PHYSICS, 2000, 87 (10) :7227-7231

[40] Energy harvesting and storage in 1D devices [J].

Sun, Hao ;

Zhang, Ye ;

Zhang, Jing ;

Sun, Xuemei ;

Peng, Huisheng .

NATURE REVIEWS MATERIALS, 2017, 2 (06)

← 1 2 3 4 5 6 →