Metal-organic frameworks (MOFs), a crystalline porous material with a periodic network structure formed by the self-assembly of transition metal ions and organic ligands, have been widely applied in various fields due to their rich composition and structural diversity. Among various types of MOFs, stimuli-responsive MOFs have gained increasing attention in recent years, because of their broad application in the field of physics, biology, and chemistry. In this review, we analyzed and classified the mechanism of stimulus-response MOFs (pH response, glucose response, GSH response, light response, temperature response) and their applications in drug delivery, adsorption and luminescence functions, magnetization and catalysis functions, probe and sensor. © 2021 Journal of Beijing Institute of Technology