Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura

被引:59
|
作者
Banerjee, Gargi [1 ,2 ]
Adams, Matthew E. [3 ]
Jaunmuktane, Zane [4 ,5 ]
Lammie, G. Alistair [6 ]
Turner, Ben [7 ,8 ]
Wani, Mushtaq [9 ]
Sawhney, Inder M. S. [9 ]
Houlden, Henry [4 ]
Mead, Simon [10 ,11 ]
Brandner, Sebastian [5 ,12 ]
Werring, David J. [1 ,2 ]
机构
[1] UCL, Stroke Res Ctr, Dept Brain Repair & Rehabil, Queen Sq Inst Neurol, Russell Sq House,10-12 Russell Sq, London WC1B 5EH, England
[2] Natl Hosp Neurol & Neurosurg, London, England
[3] Natl Hosp Neurol & Neurosurg, Lysholm Dept Neuroradiol, London, England
[4] UCL, Dept Mol Neurosci, Queen Sq Inst Neurol, London, England
[5] Natl Hosp Neurol & Neurosurg, Div Neuropathol, London, England
[6] Cardiff Univ, Dept Pathol, Cardiff, S Glam, Wales
[7] Queen Mary Univ London, Barts & London Sch Med & Dent, London, England
[8] Royal London Hosp, London, England
[9] Abertawe Bro Morgannwg Univ Hlth Board, Morriston Hosp, Swansea, W Glam, Wales
[10] UCL, Med Res Council Prion Unit, Inst Prion Dis, London, England
[11] Natl Hosp Neurol & Neurosurg, Natl Prion Clin, London, England
[12] UCL, Dept Neurodegenerat Dis, Queen Sq Inst Neurol, London, England
基金
英国医学研究理事会;
关键词
CREUTZFELDT-JAKOB-DISEASE; APP LOCUS DUPLICATION; MATER; TRANSMISSION; DEMENTIA; EMBOLIZATION; ASSOCIATION; TRIALS; GRAFT;
D O I
10.1002/ana.25407
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Amyloid-beta transmission has been described in patients both with and without iatrogenic Creutzfeldt-Jakob disease; however, there is little information regarding the clinical impact of this acquired amyloid-beta pathology during life. Here, for the first time, we describe in detail the clinical and neuroimaging findings in 3 patients with early onset symptomatic amyloid-beta cerebral amyloid angiopathy following childhood exposure to cadaveric dura (by neurosurgical grafting in 2 patients and tumor embolization in a third). Our observations provide further in vivo evidence that cerebral amyloid angiopathy might be caused by transmission of amyloid-beta seeds (prions) present in cadaveric dura and have diagnostic relevance for younger patients presenting with suspected cerebral amyloid angiopathy. Ann Neurol 2019; 1-7 ANN NEUROL 2019;85:284-290.
引用
收藏
页码:284 / 290
页数:7
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