Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura

被引：64

作者：

Banerjee, Gargi ^{[1
,2
]}

Adams, Matthew E. ^{[3
]}

Jaunmuktane, Zane ^{[4
,5
]}

Lammie, G. Alistair ^{[6
]}

Turner, Ben ^{[7
,8
]}

Wani, Mushtaq ^{[9
]}

Sawhney, Inder M. S. ^{[9
]}

Houlden, Henry ^{[4
]}

Mead, Simon ^{[10
,11
]}

Brandner, Sebastian ^{[5
,12
]}

Werring, David J. ^{[1
,2
]}

机构：

[1] UCL, Stroke Res Ctr, Dept Brain Repair & Rehabil, Queen Sq Inst Neurol, Russell Sq House,10-12 Russell Sq, London WC1B 5EH, England

[2] Natl Hosp Neurol & Neurosurg, London, England

[3] Natl Hosp Neurol & Neurosurg, Lysholm Dept Neuroradiol, London, England

[4] UCL, Dept Mol Neurosci, Queen Sq Inst Neurol, London, England

[5] Natl Hosp Neurol & Neurosurg, Div Neuropathol, London, England

[6] Cardiff Univ, Dept Pathol, Cardiff, S Glam, Wales

[7] Queen Mary Univ London, Barts & London Sch Med & Dent, London, England

[8] Royal London Hosp, London, England

[9] Abertawe Bro Morgannwg Univ Hlth Board, Morriston Hosp, Swansea, W Glam, Wales

[10] UCL, Med Res Council Prion Unit, Inst Prion Dis, London, England

[11] Natl Hosp Neurol & Neurosurg, Natl Prion Clin, London, England

[12] UCL, Dept Neurodegenerat Dis, Queen Sq Inst Neurol, London, England

来源：

ANNALS OF NEUROLOGY | 2019年 / 85卷 / 02期

基金：

英国医学研究理事会;

关键词：

CREUTZFELDT-JAKOB-DISEASE; APP LOCUS DUPLICATION; MATER; TRANSMISSION; DEMENTIA; EMBOLIZATION; ASSOCIATION; TRIALS; GRAFT;

D O I：

10.1002/ana.25407

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Amyloid-beta transmission has been described in patients both with and without iatrogenic Creutzfeldt-Jakob disease; however, there is little information regarding the clinical impact of this acquired amyloid-beta pathology during life. Here, for the first time, we describe in detail the clinical and neuroimaging findings in 3 patients with early onset symptomatic amyloid-beta cerebral amyloid angiopathy following childhood exposure to cadaveric dura (by neurosurgical grafting in 2 patients and tumor embolization in a third). Our observations provide further in vivo evidence that cerebral amyloid angiopathy might be caused by transmission of amyloid-beta seeds (prions) present in cadaveric dura and have diagnostic relevance for younger patients presenting with suspected cerebral amyloid angiopathy. Ann Neurol 2019; 1-7 ANN NEUROL 2019;85:284-290.

引用

页码：284 / 290

页数：7

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