Modular synthesis of allosteric inhibitors of p97 AAA ATPase

被引:0
|
作者
Carder, Evan [1 ]
Huryn, Donna [1 ]
Wipf, Peter [1 ]
机构
[1] Univ Pittsburgh, Pittsburgh, PA USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
214
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97
    Alverez, Celeste
    Arkin, Michelle R.
    Bulfer, Stacie L.
    Colombo, Raffaele
    Kovaliov, Marina
    LaPorte, Matthew G.
    Lim, Chaemin
    Liang, Mary
    Moore, William J.
    Neitz, R. Jeffrey
    Yan, Yongzhao
    Yue, Zhizhou
    Huryn, Donna M.
    Wipf, Peter
    ACS MEDICINAL CHEMISTRY LETTERS, 2015, 6 (12): : 1225 - 1230
  • [22] Inhibitors of p97/Cdc48 AAA ATPase as Potential Anti-Cancer Therapeutics
    Chou, Tsui-Fen
    Brown, Steven
    Rosen, Hugh
    Deshaies, Raymond J.
    FASEB JOURNAL, 2009, 23
  • [23] Allosteric p97 Inhibitors Can Overcome Resistance to ATP-Competitive p97 Inhibitors for Potential Anticancer Therapy
    Wang, Feng
    Li, Shan
    Gan, Taiping
    Stott, Gordon M.
    Flint, Andrew
    Chou, Tsui-Fen
    CHEMMEDCHEM, 2020, 15 (08) : 685 - 694
  • [24] Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors
    Nandi, Purbasha
    Devore, Kira
    Wang, Feng
    Li, Shan
    Walker, Joel D.
    Truong, Thanh Tung
    Laporte, Matthew G.
    Wipf, Peter
    Schlager, Heidi
    Mccleerey, John
    Paquette, William
    Columbres, Rod Carlo A.
    Gan, Taiping
    Poh, Yu-Ping
    Fromme, Petra
    Flint, Andrew J.
    Wolf, Mark
    Huryn, Donna M.
    Chou, Tsui-Fen
    Chiu, Po-Lin
    COMMUNICATIONS CHEMISTRY, 2024, 7 (01):
  • [25] Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
    Meyer, Hemmo
    Bug, Monika
    Bremer, Sebastian
    NATURE CELL BIOLOGY, 2012, 14 (02) : 117 - 123
  • [26] Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97
    Li, Guangtao
    Huang, Chengdong
    Zhao, Gang
    Lennarz, William J.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (10) : 3737 - 3741
  • [27] The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP
    Niwa, Hajime
    Ewens, Caroline A.
    Tsang, Chun
    Yeung, Heidi O.
    Zhang, Xiaodong
    Freemont, Paul S.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (11) : 8561 - 8570
  • [28] Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
    Hemmo Meyer
    Monika Bug
    Sebastian Bremer
    Nature Cell Biology, 2012, 14 : 117 - 123
  • [29] A Conserved Unfoldase Activity for the p97 AAA-ATPase in Proteasomal Degradation
    Beskow, Anne
    Grimberg, Kristian Bjork
    Bott, Laura C.
    Salomons, Florian A.
    Dantuma, Nico P.
    Young, Patrick
    JOURNAL OF MOLECULAR BIOLOGY, 2009, 394 (04) : 732 - 746
  • [30] The AAA+ ATPase p97 as a novel parasite and tuberculosis drug target
    Kobakhidze, George
    Sethi, Ashish
    Valimehr, Sepideh
    Ralph, Stuart A.
    Rouiller, Isabelle
    TRENDS IN PARASITOLOGY, 2022, 38 (07) : 572 - 590