The role of the kidney and the sympathetic nervous system in hypertension

被引：19
作者：
Thomas, Philip [1 ]
Dasgupta, Indranil [1 ]
机构：
[1] Birmingham Heartlands Hosp, Dept Nephrol, Birmingham B9 5ST, W Midlands, England
来源：
PEDIATRIC NEPHROLOGY | 2015年 / 30卷 / 04期
关键词：
Hypertension; Kidney; CKD; Sympathetic nervous system; Renal denervation; Pathogenesis; CHRONIC-RENAL-FAILURE; AFFERENT DENERVATION PREVENTS; CONVERTING ENZYME-INHIBITION; SALT-SENSITIVE HYPERTENSION; ARTERIAL-PRESSURE CONTROL; CONGESTIVE-HEART-FAILURE; HIGH BLOOD-PRESSURE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; RESISTANT HYPERTENSION;
D O I：
10.1007/s00467-014-2789-4
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Nearly one-third of the world's population has hypertension. The human and societal impact of hypertension is enormous. Primary hypertension accounts for 95 % of cases of hypertension in adults. The pathogenesis of primary hypertension is complex. The kidney and the sympathetic nervous system play important roles in the development and maintenance of hypertension. This review discusses their respective roles, the interaction between the two, implications of sympathetic overactivity in kidney disease and therapeutic interventions that have been developed on the basis of this knowledge, especially modulation of the sympathetic nervous system.
引用
收藏
页码：549 / 560
页数：12
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