Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces

被引：72

作者：

Cai, Xiaoming ^{[1
]}

Dong, Jun ^{[2
]}

Liu, Jing ^{[3
]}

Zheng, Huizhen ^{[1
]}

Kaweeteerawat, Chitrada ^{[4
]}

Wang, Fangjun ^{[3
]}

Ji, Zhaoxia ^{[5
,6
]}

Li, Ruibin ^{[1
]}

机构：

[1] Soochow Univ, State Key Lab Radiat Med & Protect, Sch Publ Hlth,Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiol Med,Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China

[2] Wuhan Acad Agr Sci, Wuhan 430000, Hubei, Peoples R China

[3] Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

[4] NSTDA, Natl Nanotechnol Ctr NANOTEC, Klong Nueng 12120, Thailand

[5] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA

[6] Living Proof Inc, Cambridge, MA 02142 USA

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

中国国家自然科学基金;

关键词：

OXIDE NANOPARTICLES; OXIDATIVE STRESS; BAND-GAP; IN-VITRO; PROTEIN; CELLS; TOXICITY; SPECTROSCOPY; INTEGRATION; MIGRATION;

D O I：

10.1038/s41467-018-06869-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Increasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure-activity relationship (SAR) analyses of engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views on ENM-induced bio-effects. Here we report a multi-hierarchical nano-SAR assessment for a representative ENM, Fe2O3, by metabolomics and proteomics analyses. The established nano-SAR profile allows the visualizing of the contributions of seven basic properties of Fe2O3 to its diverse bio-effects. For instance, although surface reactivity is responsible for Fe2O3-induced cell migration, the inflammatory effects of Fe2O3 are determined by aspect ratio (nanorods) or surface reactivity (nanoplates). These nano-SARs are examined in THP-1 cells and animal lungs, which allow us to decipher the detailed mechanisms including NLRP3 inflammasome pathway and monocyte chemoattractant protein-1-dependent signaling. This study provides more insights for nano-SARs, and may facilitate the tailored design of ENMs to render them desired bio-effects.

引用

页数：12

共 60 条

[1] Preparation and evaluation of nanosized mixed calcium iron oxide (CaFe2O4) as high heat resistant pigment in paints [J].