Research progress on the pharmacological effects of matrine

被引：19

作者：

Sun, Yanan ^{[1
]}

Xu, Lu ^{[2
]}

Cai, Qihan ^{[2
]}

Wang, Mengmeng ^{[2
]}

Wang, Xinliang ^{[2
]}

Wang, Siming ^{[2
]}

Ni, Zhiyu ^{[3
,4
,5
]}

机构：

[1] Hebei Univ, Coll Tradit Chinese Med, Baoding, Peoples R China

[2] Hebei Univ, Sch Basic Med Sci, Baoding, Peoples R China

[3] Hebei Univ, Affiliated Hosp, Baoding, Peoples R China

[4] Hebei Univ, Clin Med Coll, Baoding, Peoples R China

[5] Hebei Collaborat Innovat Ctr Tumor Microecol Metab, Baoding, Peoples R China

来源：

FRONTIERS IN NEUROSCIENCE | 2022年 / 16卷

关键词：

matrine; pharmacological action; toxicology; pharmacokinetics; gut and gut microbes; CANCER CELLS; OXIDATIVE STRESS; LUNG-CANCER; MOUSE MODEL; KAPPA-B; OXYMATRINE; PROLIFERATION; INFLAMMATION; ANTIOXIDANT; LIVER;

D O I：

10.3389/fnins.2022.977374

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Matrine possesses anti-cancer properties, as well as the prevention and treatment of allergic asthma, and protection against cerebral ischemia-reperfusion injury. Its mechanism of action may be (1) regulation of cancer cell invasion, migration, proliferation, and cell cycle to inhibit tumor growth; (2) reduction of oxidized low-density lipoprotein and advanced glycation end products from the source by exerting anti-inflammatory and antioxidant effects; (3) protection of brain damage and cortical neurons by regulating apoptosis; (4) restoration of the intestinal barrier and regulation of the intestinal microbiota. This article aims to explore matrine's therapeutic potential by summarizing comprehensive information on matrine's pharmacology, toxicity, and bioavailability.

引用

页数：9

共 67 条

[1] Tubulin-binding agents down-regulate matrix metalloproteinase-2 and-9 in human hormone-refractory prostate cancer cells - A critical role of Cdk1 in mitotic entry
Chang, Wei-Ling
Yu, Chia-Chun
Chen, Ching-Shih
Guh, Jih-Hwa
[J]. BIOCHEMICAL PHARMACOLOGY, 2015, 94 (01) : 12 - 21
[2] HSP60 is involved in the neuroprotective effects of naloxone
Cheng, Wenjing
Li, Yunhong
Hou, Xiaolin
Zhang, Nan
Ma, Jiao
Ding, Feijia
Li, Fan
Miao, Zhenhua
Zhang, Yanli
Qi, Qi
Li, Guanghua
Shen, Ying
Liu, Juan
Huang, Weidong
Wang, Yin
[J]. MOLECULAR MEDICINE REPORTS, 2014, 10 (04) : 2172 - 2176
[3] Dong XQ, 2013, IRAN J PHARM RES, V12, P165
[4] Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury
Dong, Xiao-Qiao
Yu, Wen-Hua
Hu, Yue-Yu
Zhang, Zu-Yong
Huang, Man
[J]. INFLAMMATION RESEARCH, 2011, 60 (06) : 533 - 539
[5] Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1
Drucker, Daniel J.
[J]. CELL METABOLISM, 2018, 27 (04) : 740 - 756
[6] Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice
Dun Linglu
Li Yuxiang
Xu Yaqiong
Zhou Ru
Ma Lin
Jin Shaoju
Du Juan
Sun Tao
Yu Jianqiang
[J]. NEUROLOGICAL SCIENCES, 2014, 35 (06) : 815 - 821
[7] Network meta-analysis of Chinese herb injections combined with FOLFOX chemotherapy in the treatment of advanced colorectal cancer
Ge, L.
Wang, Y-f.
Tian, J-h.
Mao, L.
Zhang, J.
Zhang, J-h.
Shen, X-p.
Yang, K-h.
[J]. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2016, 41 (04) : 383 - 391
[8] Oxymatrine attenuates brain hypoxic-ischemic injury from apoptosis and oxidative stress: role of p-Akt/GSK3β/HO-1/Nrf-2 signaling pathway
Ge, Xu-Hua
Shao, Li
Zhu, Guo-Ji
[J]. METABOLIC BRAIN DISEASE, 2018, 33 (06) : 1869 - 1875
[9] Neuroprotective Effect of Matrine in Mouse Model of Vincristine-Induced Neuropathic Pain
Gong, Shuai-Shuai
Li, Yu-Xiang
Zhang, Meng-Ting
Du, Juan
Ma, Peng-Sheng
Yao, Wan-Xia
Zhou, Ru
Niu, Yang
Sun, Tao
Yu, Jian-Qiang
[J]. NEUROCHEMICAL RESEARCH, 2016, 41 (11) : 3147 - 3159
[10] Effect of matrine on primary human hepatocytes in vitro
Gong, Xiaobing
Gao, Yuan
Guo, Guoqing
Vondran, Florian W. R.
Schwartlander, Ruth
Efimova, Ekaterina
Pless, Gesine
Sauera, Igor M.
Neuhaus, Peter
[J]. CYTOTECHNOLOGY, 2015, 67 (02) : 255 - 265

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