Bringing amyloid into focus

被引：12
作者：
Golde, TE
Bacskai, BJ
机构：
[1] Mayo Clin, Coll Med, Dept Neurosci, Jacksonville, FL 32224 USA
[2] Massachusetts Gen Hosp, Alzheimers Dis Res Unit, Charlestown, MA 02129 USA
来源：
NATURE BIOTECHNOLOGY | 2005年 / 23卷 / 05期
关键词：
D O I：
10.1038/nbt0505-552
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Amyloid deposits can be rapidly detected in the brains of living mice using a novel ligand and near-infrared fluorescence imaging.
引用
收藏
页码：552 / 554
页数：4
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共 14 条
  • [1] In vivo near-infrared fluorescence imaging
    Frangioni, JV
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2003, 7 (05) : 626 - 634
  • [2] Alzheimer disease therapy: Can the amyloid cascade be halted?
    Golde, TE
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (01) : 11 - 18
  • [3] A submillimeter resolution fluorescence molecular imaging system for small animal imaging
    Graves, EE
    Ripoll, J
    Weissleder, R
    Ntziachristos, V
    [J]. MEDICAL PHYSICS, 2003, 30 (05) : 901 - 911
  • [4] 19F and 1H MRI detection of amyloid β plaques in vivo
    Higuchi, M
    Iwata, N
    Matsuba, Y
    Sato, K
    Sasamoto, K
    Saido, TC
    [J]. NATURE NEUROSCIENCE, 2005, 8 (04) : 527 - 533
  • [5] In vivo detection of amyloid-β deposits by near-infrared imaging using an oxazine-derivative probe
    Hintersteiner, M
    Enz, A
    Frey, P
    Jaton, AL
    Kinzy, W
    Kneuer, R
    Neumann, U
    Rudin, M
    Staufenbiel, M
    Stoeckli, M
    Wiederhold, KH
    Gremlich, HU
    [J]. NATURE BIOTECHNOLOGY, 2005, 23 (05) : 577 - 583
  • [6] In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent
    Jack, CR
    Garwood, M
    Wengenack, TM
    Borowski, B
    Curran, GL
    Lin, J
    Adriany, G
    Gröhn, IHJ
    Grimm, R
    Poduslo, JF
    [J]. MAGNETIC RESONANCE IN MEDICINE, 2004, 52 (06) : 1263 - 1271
  • [7] Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    Klunk, WE
    Engler, H
    Nordberg, A
    Wang, YM
    Blomqvist, G
    Holt, DP
    Bergström, M
    Savitcheva, I
    Huang, GF
    Estrada, S
    Ausén, B
    Debnath, ML
    Barletta, J
    Price, JC
    Sandell, J
    Lopresti, BJ
    Wall, A
    Koivisto, P
    Antoni, G
    Mathis, CA
    Långström, B
    [J]. ANNALS OF NEUROLOGY, 2004, 55 (03) : 306 - 319
  • [8] Visualization of β-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents
    Lee, SP
    Falangola, MF
    Nixon, RA
    Duff, K
    Helpern, JA
    [J]. MAGNETIC RESONANCE IN MEDICINE, 2004, 52 (03) : 538 - 544
  • [9] Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability, and in vivo targeting to Alzheimer's disease amyloid plaques
    Poduslo, JF
    Curran, GL
    Peterson, JA
    McCormick, DJ
    Fauq, AH
    Khan, MA
    Wengenack, TM
    [J]. BIOCHEMISTRY, 2004, 43 (20) : 6064 - 6075
  • [10] Spatial/temporal correlation of BOLD and optical intrinsic signals in humans
    Pouratian, N
    Sicotte, N
    Rex, D
    Martin, NA
    Becker, D
    Cannestra, AF
    Toga, AW
    [J]. MAGNETIC RESONANCE IN MEDICINE, 2002, 47 (04) : 766 - 776
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