Fecal microbiota transplantation for recurrent Clostridium difficile infection in children

被引：13

作者：

Chen, Becky ^{[1
]}

Avinashi, Vishal ^{[1
]}

Dobson, Simon ^{[2
]}

机构：

[1] British Columbia Childrens Hosp, Div Gastroenterol Hepatol & Nutr, Vancouver, BC, Canada

[2] British Columbia Childrens Hosp, Div Infect Dis, Vancouver, BC, Canada

来源：

JOURNAL OF INFECTION | 2017年 / 74卷

关键词：

Clostridium difficile; Fecal microbiota transplantation; Microbiome; INFLAMMATORY-BOWEL-DISEASE; RISK-FACTORS; HOSPITALIZED CHILDREN; HYPERVIRULENT STRAIN; PEDIATRIC-PATIENTS; UNITED-STATES; DIARRHEA; EPIDEMIOLOGY; MORTALITY; INFANTS;

D O I：

10.1016/S0163-4453(17)30202-5

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Fecal microbiota transplantation (FMT) is a relatively simple, promising treatment for recurrent Clostridium difficile infection. While there are a wide variety of approaches including mode of delivery, the results are nonetheless encouraging, even amongst younger children. Experience with FMT in the pediatric population is increasing, showing similar success compared to adults. This article will provide an overview of C. difficile infection along with review of the rationale, methods and complications of FMT including the current experience of FMT in children. (C) 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

引用

页码：S120 / S127

页数：8

共 73 条

[31] Changes in the Composition of the Human Fecal Microbiome After Bacteriotherapy for Recurrent Clostridium difficile-associated Diarrhea [J].

Khoruts, Alexander ;

Dicksved, Johan ;

Jansson, Janet K. ;

Sadowsky, Michael J. .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2010, 44 (05) :354-360

[32] Epidemiological Features of Clostridium difficile-Associated Disease Among Inpatients at Children's Hospitals in the United States, 2001-2006 [J].

Kim, Jason ;

Smathers, Sarah A. ;

Prasad, Priya ;

Leckerman, Kateri H. ;

Coffin, Susan ;

Zaoutis, Theoklis .

PEDIATRICS, 2008, 122 (06) :1266-1270

[33] Risk Factors for Recurrent Clostridium difficile Infection in Children: A Nested Case-Control Study [J].

Kociolek, Larry K. ;

Palac, Hannah L. ;

Patel, Sameer J. ;

Shulman, Stanford T. ;

Gerding, Dale N. .

JOURNAL OF PEDIATRICS, 2015, 167 (02) :384-389

[34] Fecal Microbiota Transplantation Via Nasogastric Tube for Recurrent Clostridium difficile Infection in Pediatric Patients [J].

Kronman, Matthew P. ;

Nielson, Heather J. ;

Adler, Amanda L. ;

Giefer, Matthew J. ;

Wahbeh, Ghassan ;

Singh, Namita ;

Zerr, Danielle M. ;

Suskind, David L. .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2015, 60 (01) :23-26

[35] Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile [J].

Kyne, L ;

Hamel, MB ;

Polavaram, R ;

Kelly, CNP .

CLINICAL INFECTIOUS DISEASES, 2002, 34 (03) :346-353

[36]

Lamont J Thomas, 2002, Trans Am Clin Climatol Assoc, V113, P167

[37] Polymerase Chain Reaction Test for Clostridium difficile Toxin B Gene Reveals Similar Prevalence Rates in Children With and Without Inflammatory Bowel Disease [J].

Lamouse-Smith, Esi S. N. ;

Weber, Sarah ;

Rossi, Richard F. ;

Neinstedt, Liliane J. ;

Mosammaparast, Nima ;

Sandora, Thomas J. ;

McAdam, Alexander J. ;

Bousvaros, Athos .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2013, 57 (03) :293-297

[38] Clostridium difficile Infection [J].

McDonald, Emily G. ;

Lee, Todd C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (03) :286-286

[39] A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality [J].

Loo, VG ;

Poirier, L ;

Miller, MA ;

Oughton, M ;

Libman, MD ;

Michaud, S ;

Bourgault, AM ;

Nguyen, T ;

Frenette, C ;

Kelly, M ;

Vibien, A ;

Brassard, P ;

Fenn, S ;

Dewar, K ;

Hudson, TJ ;

Horn, R ;

René, P ;

Monczak, Y ;

Dascal, A .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (23) :2442-2449

[40] Rapid Stool-Based Diagnosis of Clostridium difficile Infection by Real-Time PCR in a Children's Hospital [J].

Luna, Ruth Ann ;

Boyanton, Bobby L., Jr. ;

Mehta, Seema ;

Courtney, Ebony M. ;

Webb, C. Renee ;

Revell, Paula A. ;

Versalovic, James .

JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (03) :851-857

← 1 2 3 4 5 6 7 8 →