Janus Kinase 2: An Epigenetic 'Writer' that Activates Leukemogenic Genes

被引：10
作者：
He, Jin [1 ]
Zhang, Yi [1 ]
机构：
[1] Univ N Carolina, Dept Biochem & Biophys, Lineberger Comprehens Canc Ctr, Howard Hughes Med Inst, Chapel Hill, NC 27599 USA
来源：
JOURNAL OF MOLECULAR CELL BIOLOGY | 2010年 / 2卷 / 05期
关键词：
MYELOPROLIFERATIVE DISORDERS; JAK2; DOMAIN;
D O I：
10.1093/jmcb/mjp054
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Activation of Janus kinase 2 (JAK2) plays a critical role in normal hematopoiesis and leukemogenesis. Dawson et al. (2009; JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461, 819-822) report that JAK2 performs this function by displacing the heterochromatin protein HP1 alpha from chromatin through phosphorylation of histone H3.
引用
收藏
页码：231 / 233
页数：3
相关论文
共 11 条
  • [1] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
    Bannister, AJ
    Zegerman, P
    Partridge, JF
    Miska, EA
    Thomas, JO
    Allshire, RC
    Kouzarides, T
    [J]. NATURE, 2001, 410 (6824) : 120 - 124
  • [2] JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin
    Dawson, Mark A.
    Bannister, Andrew J.
    Goettgens, Berthold
    Foster, Samuel D.
    Bartke, Till
    Green, Anthony R.
    Kouzarides, Tony
    [J]. NATURE, 2009, 461 (7265) : 819 - U79
  • [3] Establishment and maintenance of a heterochromatin domain
    Hall, IM
    Shankaranarayana, GD
    Noma, KI
    Ayoub, N
    Cohen, A
    Grewal, SIS
    [J]. SCIENCE, 2002, 297 (5590) : 2232 - 2237
  • [4] Jak2: normal function and role in hematopoietic disorders
    Ihle, James N.
    Gilliland, D. Gary
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2007, 17 (01) : 8 - 14
  • [5] Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency
    McCormack, MP
    Rabbitts, TH
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (09) : 913 - 922
  • [6] Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
    Neubauer, H
    Cumano, A
    Muller, M
    Wu, H
    Huffstadt, U
    Pfeffer, K
    [J]. CELL, 1998, 93 (03) : 397 - 409
  • [7] Jak2 is essential for signaling through a variety of cytokine receptors
    Parganas, E
    Wang, D
    Stravopodis, D
    Topham, DJ
    Marine, JC
    Teglund, S
    Vanin, EF
    Bodner, S
    Colamonici, OR
    van Deursen, JM
    Grosveld, G
    Ihle, JN
    [J]. CELL, 1998, 93 (03) : 385 - 395
  • [8] JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders
    Plo, Isabelle
    Nakatake, Mayuka
    Malivert, Laurent
    de Villartay, Jean-Pierre
    Giraudier, Stephane
    Villeval, Jean-Luc
    Wiesmuller, Lisa
    Vainchenker, William
    [J]. BLOOD, 2008, 112 (04) : 1402 - 1412
  • [9] Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2
    Schwaller, J
    Parganas, E
    Wang, DM
    Cain, D
    Aster, JC
    Williams, IR
    Lee, CK
    Gerthner, R
    Kitamura, T
    Frantsve, J
    Anastasiadou, E
    Loh, ML
    Levy, DE
    Ihle, JN
    Gilliland, DG
    [J]. MOLECULAR CELL, 2000, 6 (03) : 693 - 704
  • [10] JAK signaling globally counteracts heterochromatic gene silencing
    Shi, Song
    Calhoun, Healani C.
    Xia, Fan
    Li, Jinghong
    Le, Long
    Li, Willis X.
    [J]. NATURE GENETICS, 2006, 38 (09) : 1071 - 1076
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