How Mitochondrial Dynamism Orchestrates Mitophagy

被引：265

作者：

Shirihai, Orian S. ^{[1
,2
]}

Song, Moshi ^{[3
]}

Dorn, Gerald W., II ^{[3
]}

机构：

[1] Boston Univ, Sch Med, Evans Ctr, Dept Med, Boston, MA 02215 USA

[2] Ben Gurion Univ Negev, Dept Biochem, IL-84105 Beer Sheva, Israel

[3] Washington Univ, Sch Med, Dept Internal Med, Ctr Pharmacogen, St Louis, MO 63110 USA

来源：

CIRCULATION RESEARCH | 2015年 / 116卷 / 11期

基金：

美国国家卫生研究院;

关键词：

autophagy; mitochondria; mitochondrial dynamics; Parkinson disease; PARKIN-MEDIATED MITOPHAGY; DOMINANT OPTIC ATROPHY; E3 UBIQUITIN LIGASE; LOSS-OF-FUNCTION; MITOFUSIN; PINK1-DEPENDENT PHOSPHORYLATION; EMBRYONIC-DEVELOPMENT; DAMAGED MITOCHONDRIA; CARDIAC MITOCHONDRIA; ELECTRON-TRANSPORT;

D O I：

10.1161/CIRCRESAHA.116.306374

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mitochondria are highly dynamic, except in adult cardiomyocytes. Yet, the fission and fusion-promoting proteins that mediate mitochondrial dynamism are highly expressed in, and essential to the normal functioning of, hearts. Here, we review accumulating evidence supporting important roles for mitochondrial fission and fusion in cardiac mitochondrial quality control, focusing on the PTEN-induced putative kinase 1-Parkin mitophagy pathway. Based in part on recent findings from in vivo mouse models in which mitofusin-mediated mitochondrial fusion or dynamin-related protein 1-mediated mitochondrial fission was conditionally interrupted in cardiac myocytes, we propose several new concepts that may provide insight into the cardiac mitochondrial dynamism-mitophagy interactome.

引用

页码：1835 / 1849

页数：15

共 156 条

[21] A novel protein, Romo1, induces ROS production in the mitochondria [J].

Chung, Young Min ;

Kim, Jun Suk ;

Yoo, Young Do .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 347 (03) :649-655

[22] Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin [J].

Clark, Ira E. ;

Dodson, Mark W. ;

Jiang, Changan ;

Cao, Joseph H. ;

Huh, Jun R. ;

Seol, Jae Hong ;

Yoo, Soon Ji ;

Hay, Bruce A. ;

Guo, Ming .

NATURE, 2006, 441 (7097) :1162-1166

[23] Fission Yeast Does Not Age under Favorable Conditions, but Does So after Stress [J].

Coelho, Miguel ;

Dereli, Ayguel ;

Haese, Anett ;

Kuehn, Sebastian ;

Malinovska, Liliana ;

DeSantis, Morgan E. ;

Shorter, James ;

Alberti, Simon ;

Gross, Thilo ;

Tolic-Norrelykke, Iva M. .

CURRENT BIOLOGY, 2013, 23 (19) :1844-1852

[24] Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency [J].

Cogliati, Sara ;

Frezza, Christian ;

Soriano, Maria Eugenia ;

Varanita, Tatiana ;

Quintana-Cabrera, Ruben ;

Corrado, Mauro ;

Cipolat, Sara ;

Costa, Veronica ;

Casarin, Alberto ;

Gomes, Ligia C. ;

Perales-Clemente, Ester ;

Salviati, Leonardo ;

Fernandez-Silva, Patricio ;

Enriquez, Jose A. ;

Scorrano, Luca .

CELL, 2013, 155 (01) :160-171

[25] WHAT GENETICS TELLS US ABOUT THE CAUSES AND MECHANISMS OF PARKINSON'S DISEASE [J].

Corti, Olga ;

Lesage, Suzanne ;

Brice, Alexis .

PHYSIOLOGICAL REVIEWS, 2011, 91 (04) :1161-1218

[26] Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function [J].

Davies, Vanessa J. ;

Hollins, Andrew J. ;

Piechota, Malgorzata J. ;

Yip, Wanfen ;

Davies, Jennifer R. ;

White, Kathryn E. ;

Nicols, Phillip P. ;

Boulton, Michael E. ;

Votruba, Marcela .

HUMAN MOLECULAR GENETICS, 2007, 16 (11) :1307-1318

[27] Mitofusin 2 tethers endoplasmic reticulum to mitochondria [J].

de Brito, Olga Martins ;

Scorrano, Luca .

NATURE, 2008, 456 (7222) :605-U47

[28] Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy [J].

Delettre, C ;

Lenaers, G ;

Griffoin, JM ;

Gigarel, N ;

Lorenzo, C ;

Belenguer, P ;

Pelloquin, L ;

Grosgeorge, J ;

Turc-Carel, C ;

Perret, E ;

Astarie-Dequeker, C ;

Lasquellec, L ;

Arnaud, B ;

Ducommun, B ;

Kaplan, J ;

Hamel, CP .

NATURE GENETICS, 2000, 26 (02) :207-210

[29] Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long-term Cardiac Dysfunction [J].

Disatnik, Marie-Helene ;

Ferreira, Julio C. B. ;

Campos, Juliane Cruz ;

Gomes, Katia Sampaio ;

Dourado, Paulo M. M. ;

Qi, Xin ;

Mochly-Rosen, Daria .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2013, 2 (05)

[30] Functional implications of mitofusin 2-mediated mitochondrial-SR tethering [J].

Dorn, Gerald W., II ;

Song, Moshi ;

Walsh, Kenneth .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2015, 78 :123-128

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