Autoimmune-mediated secondary-parkinsonism presented with micrographia and cognitive impairment

被引：3

作者：

Che, Ning-Ning ^{[1
,3
]}

Chen, Si-Yuan ^{[1
]}

Li, Xue ^{[1
]}

Ma, Jian-Jun ^{[1
]}

Yang, Hong-Qi ^{[1
,2
]}

机构：

[1] Henan Univ, Henan Prov Peoples Hosp, Sch Clin Med, Dept Neurol, Zhengzhou 450003, Peoples R China

[2] Zhengzhou Univ, Henan Prov Peoples Hosp, Sch Clin Med, Dept Neurol, Zhengzhou 450003, Peoples R China

[3] Nanjing Med Univ, Dept Neurol, Affiliated BenQ Hosp, Nanjing 210019, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 361卷

关键词：

Parkinsonism; Anti-NMDAR antibody; Micrographia; Cognitive impairment;

D O I：

10.1016/j.jneuroim.2021.577738

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Parkinson's disease is a neurodegenerative disorder while secondary-parkinsonism can be caused by infectious, inflammatory, traumatic, vascular, hereditary, paraneoplastic, or even induced by drug/metal poisoning. Here we report an uncommon subacute parkinsonism who presented with micrographia and mild cognitive impairment. The CSF examination showed inflammatory profile and positive anti-NMDAR antibody. The patient showed no improvement with levodopa/benserazide administration but satisfactory response to immunotherapy with methylprednisolone. This case indicated that autoimmune etiology should also be considered in parkinsonism to exclude a treatable condition.

引用

页数：3