Neonatal diabetes -: The role of KCNJ11 (Kir6.2)

被引：0
|
作者：
Tammaro, Paolo [1 ]
机构：
[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England
来源：
CONGENITAL ENDOCRINOPATHIES: NEW INSIGHTS INTO ENDOCRINE DISEASES AND DIABETES | 2007年 / 11卷
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中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
ATP-sensitive potassium (K-ATP) channels are inhibited by intracellular ATP and activated by MgADP. As a consequence, they couple the metabolic state of the cell to its electrical activity. In pancreatic P-cells KATp channels regulate glucose-dependent insulin secretion and are the target for sulphonylurea drugs clinically employed in the treatment of type 2 diabetes. This review discusses recent advances in our understanding of the role of KATp channels in permanent neonatal diabetes mellitus. Copyright (C) 2007 S. Karger AG, Basel.
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页码：70 / 82
页数：13
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