Endosome-to-TGN Trafficking: Organelle-Vesicle and Organelle-Organelle Interactions

被引:55
|
作者
Tu, Yingfeng [1 ]
Zhao, Lin [1 ]
Billadeau, Daniel D. [2 ]
Jia, Da [1 ]
机构
[1] Sichuan Univ, West China Univ Hosp 2, Dept Paediat, State Key Lab Biotherapy,Key Lab Birth Defects &, Chengdu, Peoples R China
[2] Mayo Clin, Schulze Ctr Novel Therapeut, Div Oncol Res, Rochester, MN USA
基金
中国国家自然科学基金;
关键词
endosome; TGN; human disease; membrane trafficking; membrane contact site; golgin; WASH complex; TRANS-GOLGI NETWORK; WASH COMPLEX; RETROGRADE TRANSPORT; RETROMER COMPLEX; ARP2/3; ACTIVATOR; COAT COMPLEX; INTRACELLULAR TRAFFICKING; CARGO RECOGNITION; PROTEIN COMPLEXES; SORTING MOTIF;
D O I
10.3389/fcell.2020.00163
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Retrograde transport from endosomes to the trans-Golgi network (TGN) diverts proteins and lipids away from lysosomal degradation. It is essential for maintaining cellular homeostasis and signaling. In recent years, significant advancements have been made in understanding this classical pathway, revealing new insights into multiple steps of vesicular trafficking as well as critical roles of ER-endosome contacts for endosomal trafficking. In this review, we summarize up-to-date knowledge about this trafficking pathway, in particular, mechanisms of cargo recognition at endosomes and vesicle tethering at the TGN, and contributions of ER-endosome contacts.
引用
收藏
页数:13
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