Visible-Light-Mediated Synthesis of α-Halomethyl Ketones from Terminal Alkynes

被引：2
作者：
Shah, Iftkhar Hussain [1 ,3 ]
Kumar, Sourav [1 ,3 ]
Kumar, Jaswant [1 ,3 ]
Raheem, Shabnam [2 ]
Rizvi, Masood Ahmad [2 ]
Shah, Bhahwal Ali [1 ,3 ]
机构：
[1] Acad Sci & Ind Res AcSIR, Ghaziabad 201002, India
[2] Univ Kashmir, Srinagar 190006, India
[3] CSIR Indian Inst Integrat Med, Nat Prod & Med Chem, Canal Rd, Jammu 180001, India
来源：
CHEMPHOTOCHEM | 2022年 / 6卷 / 03期
关键词：
alpha-halomethyl ketones; alkynes; N-halosuccinimide; radicals; trifluoroacetic acid; CATALYZED HYDRATION; N-HALOSUCCINIMIDES; CASCADE REACTION; MILD; HALOGENATION; FUNCTIONALIZATION; HALOKETONES; DERIVATIVES; HALOALKYNES; CONVENIENT;
D O I：
10.1002/cptc.202100231
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A visible-light-assisted approach for the synthesis of alpha-halomethyl ketones from terminal alkynes has been developed. The reaction introduces halogen at the alpha-position of terminal alkynes using N-halosuccinimides as the halogen source. It relies on the photodegradation of N-halosuccinimides obviating the requirement for a photocatalyst. The procedure enables the synthesis of a diverse range of alpha-haloketones from different aromatic bromo- and iodoalkynes.
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页数：5
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