An innovative method to selectively ablate cholesterol esters from an arteriosclerotic region of the arterial wall using a free-electron laser

被引：8
作者：
Awazu, K
Nagai, A
Tomimasu, T
Aizawa, K
机构：
[1] Free Electron Laser Res Inst, Adv Mat Grp, Hirakata, Osaka 57301, Japan
[2] Tokyo Med Coll, Dept Physiol, Tokyo 160, Japan
来源：
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS | 1998年 / 144卷 / 1-4期
关键词：
free electron laser; cholesteryl oleate; atherosclerosis; ablation;
D O I：
10.1016/S0168-583X(98)00309-7
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
The selective removal of cholesterol esters accumulated in the intra-cellular or extra-cellular spaces has clinical significance. In the present work we investigate the removal of cholesterol esters by using a free electron laser (FEL) in an arteriosclerotic region. Thin films of cholesteryl oleate and albumin, and the cross-section of a rabbit artery were placed on an inverted microscope stage and the changes caused by the FEL irradiation of 5.75 and 6.1 mu m with 1.5-3 mW in average were monitored continuously by a CCD camera in real time. FEL irradiation at a wavelength of 5.75 mu m, which is a stretching vibrational mode of the ester, was able to ablate cholesterol esters without affecting albumin and that it can also remove cholesterol esters from rabbits' arteriosclerotic arterial walls. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：225 / 228
页数：4
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