Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

被引：26

作者：

Kluzek, Monika ^{[1
]}

Tyler, Arwen I. I. ^{[2
,3
]}

Wang, Shiqi ^{[4
]}

Chen, Rongjun ^{[4
]}

Marques, Carlos M. ^{[1
]}

Thalmann, Fabrice ^{[1
]}

Seddon, John M. ^{[2
]}

Schmutz, Marc ^{[1
]}

机构：

[1] Univ Strasbourg, CNRS, Inst Charles Sadron, UPR022, 23 Rue Loess, F-67034 Strasbourg, France

[2] Imperial Coll London, Dept Chem, South Kensington Campus, London SW7 2AZ, England

[3] Univ Leeds, Sch Food Sci & Nutr, Food Colloids & Proc Grp, Leeds LS2 9JT, W Yorkshire, England

[4] Imperial Coll London, Dept Chem Engn, South Kensington Campus, London SW7 2AZ, England

来源：

SOFT MATTER | 2017年 / 13卷 / 41期

关键词：

LYOTROPIC LIQUID-CRYSTALS; BICONTINUOUS CUBIC PHASE; DRUG-DELIVERY SYSTEMS; RESPONSIVE POLYMERS; WATER CHANNELS; X-RAY; DISPERSIONS; RELEASE; MEMBRANE; DIOLEOYLPHOSPHATIDYLSERINE/MONOOLEIN;

D O I：

10.1039/c7sm01620d

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Cubosomes consist in submicron size particles of lipid bicontinuous cubic phases stabilized by surfactant polymers. They provide an appealing road towards the practical use of lipid cubic phases for pharmaceutical and cosmetic applications, and efforts are currently being made to control the encapsulation and release properties of these colloidal objects. We overcome in this work the lack of sensitivity of monoolein cubosomes to pH conditions by using a pH sensitive polymer designed to strongly interact with the lipid structure at low pH. Our cryo-transmission electron microscope (cryo-TEM) and small-angle X-ray scattering (SAXS) results show that in the presence of the polymer the cubic phase structure is preserved at neutral pH, albeit with a larger cell size. At pH 5.5, in the presence of the polymer, the nanostructure of the cubosome particles is significantly altered, providing a pathway to design pH-responsive cubosomes for applications in drug delivery.

引用

页码：7571 / 7577

页数：7

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