Pharmapolymers in the 21st century: Synthetic polymers in drug delivery applications

被引：175

作者：

Englert, Christoph ^{[1
,2
]}

Brendel, Johannes C. ^{[1
,2
]}

Majdanski, Tobias C. ^{[1
,2
]}

Yildirim, Turgay ^{[1
,2
]}

Schubert, Stephanie ^{[2
,3
]}

Gottschaldt, Michael ^{[1
,2
]}

Windhab, Norbert ^{[4
]}

Schubert, Ulrich S. ^{[1
,2
]}

机构：

[1] Friedrich Schiller Univ Jena, Lab Organ & Macromol Chem IOMC, Humboldtstr 10, D-07743 Jena, Germany

[2] Friedrich Schiller Univ Jena, JCSM, Philosophenweg 7, D-07743 Jena, Germany

[3] Friedrich Schiller Univ Jena, Dept Pharmaceut Technol & Biopharm, Lessingstr 8, D-07743 Jena, Germany

[4] Evon Nutr & Care GmbH, Kirschenallee, D-64293 Darmstadt, Germany

来源：

PROGRESS IN POLYMER SCIENCE | 2018年 / 87卷

关键词：

Pharmapolymers; Drug delivery; Market; Clinical trials; Structure-activity relationships; RING-OPENING POLYMERIZATION; BARE-METAL STENTS; PHASE-III TRIAL; MOLECULAR-WEIGHT POLYACRYLONITRILE; SYSTEMICALLY ADMINISTERED SIRNA; TRANSFER RADICAL POLYMERIZATION; CONTROLLED-RELEASE FORMULATION; PACLITAXEL POLIGLUMEX CT-2103; ETIRINOTECAN PEGOL NKTR-102; LINKED POLY(VINYL ALCOHOL);

D O I：

10.1016/j.progpolymsci.2018.07.005

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The administration of drugs, as a main challenge of pharmaceutical and medicinal applications, has certainly benefited from the application of synthetic polymers. However, despite an enormous effort to develop new materials for drug delivery applications, only few of them have entered the market due to the hurdles of regulation, production, cost efficiency and both industrial's and patients' acceptance. In this review, we summarize all these classes of synthetic polymers, which are on the market as well as the latest developments in clinical trials, and describe their application in polymer-drug conjugates, as excipients, in nano-/microscopic and macroscopic drug carriers, as polymeric coatings, or as polymeric drugs. Our intention is to create a link between the underlying chemical structures, the properties of the polymers, and their area of application, where they are often just known by their trade names or abbreviations. In addition selected types of synthetic polymers are highlighted that feature interesting properties and have the potential to make it to the market in future. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：107 / 164

页数：58

共 727 条

[21] A THEORETICAL BASIS FOR A BIOPHARMACEUTIC DRUG CLASSIFICATION - THE CORRELATION OF IN-VITRO DRUG PRODUCT DISSOLUTION AND IN-VIVO BIOAVAILABILITY [J].