Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres

被引:52
作者
Gee, Dylan G. [1 ]
Biswal, Bharat B. [2 ,3 ]
Kelly, Clare [1 ]
Stark, David E. [4 ]
Margulies, Daniel S. [5 ]
Shehzad, Zarrar [1 ]
Uddin, Lucina Q. [6 ]
Klein, Donald F. [1 ,2 ]
Banich, Marie T. [7 ]
Castellanos, F. Xavier [1 ,2 ]
Milham, Michael P. [1 ,2 ]
机构
[1] NYU Langone Med Ctr, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY 10016 USA
[2] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
[3] Univ Med & Dent New Jersey, Dept Radiol, Newark, NJ 07101 USA
[4] Harvard Univ, Sch Med, Boston, MA 02115 USA
[5] Humboldt Univ, Berlin Sch Mind & Brain, D-10099 Berlin, Germany
[6] Stanford Univ, Sch Med, Dept Psychiat, Stanford, CA 94304 USA
[7] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA
关键词
INTRINSIC FUNCTIONAL ARCHITECTURE; RESTING-STATE NETWORKS; HUMAN BRAIN; INTERHEMISPHERIC INHIBITION; GLOBAL SIGNAL; EEG COHERENCE; CONNECTIVITY; ASYMMETRY; CAPACITY; OPTIMIZATION;
D O I
10.1016/j.neuroimage.2010.05.073
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Resting-state functional magnetic resonance imaging (fMRI) has provided a novel approach for examining interhemispheric interaction, demonstrating a high degree of functional connectivity between homotopic regions in opposite hemispheres. However, heterotopic resting-state functional connectivity (RSFC) remains relatively uncharacterized. In the present study, we examine non-homotopic regions, characterizing heterotopic RSFC and comparing it to intrahemispheric RSFC, to examine the impact of hemispheric separation on the integration and segregation of processing in the brain. Resting-state fMRI scans were acquired from 59 healthy participants to examine inter-regional correlations in spontaneous low frequency fluctuations in BOLD signal. Using a probabilistic atlas, we correlated probability-weighted time series from 112 regions (56 per hemisphere) distributed throughout the entire cerebrum. We compared RSFC for pairings of non-homologous regions located in different hemispheres (heterotopic connectivity) to RSFC for the same pairings when located within hemisphere (intrahemispheric connectivity). For positive connections, connectivity strength was greater within each hemisphere, consistent with integrated intrahemispheric processing. However, for negative connections, RSFC strength was greater between the hemispheres, consistent with segregated interhemispheric processing. These patterns were particularly notable for connections involving frontal and heteromodal regions. The distribution of positive and negative connectivity was nearly identical within and between the hemispheres, though we demonstrated detailed regional variation in distribution. We discuss implications for leading models of interhemispheric interaction. The future application of our analyses may provide important insight into impaired interhemispheric processing in clinical and aging populations. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:517 / 527
页数:11
相关论文
共 80 条
[1]  
Andersson JLR., 2010, FMRIB Technical Report TR07JA2
[2]  
[Anonymous], 2007, TR07JA1 FMRIB
[3]  
[Anonymous], 2000, PRINCIPLES BEHAVIOUR
[4]   Impaired interhemispheric interactions in patients with major depression [J].
Bajwa, Sami ;
Bermpohl, Felix ;
Rigonatti, Sergio P. ;
Pascual-Leone, Alvaro ;
Boggio, Paulo S. ;
Fregni, Felipe .
JOURNAL OF NERVOUS AND MENTAL DISEASE, 2008, 196 (09) :671-677
[5]   A life-span perspective on interaction between the cerebral hemispheres [J].
Banich, MT ;
Brown, WS .
DEVELOPMENTAL NEUROPSYCHOLOGY, 2000, 18 (01) :1-10
[6]  
Banich MT, 2003, ASYMMETRICAL BRAIN, P261
[7]   INTERHEMISPHERIC INTERACTION - HOW DO THE HEMISPHERES DIVIDE-AND-CONQUER A TASK [J].
BANICH, MT ;
BELGER, A .
CORTEX, 1990, 26 (01) :77-94
[8]   Separating respiratory-variation-related neuronal-activity-related fluctuations in fluctuations from fMRI [J].
Birn, RM ;
Diamond, JB ;
Smith, MA ;
Bandettini, PA .
NEUROIMAGE, 2006, 31 (04) :1536-1548
[9]   LEFT-RIGHT ASYMMETRY OF CALLOSAL TRANSFER IN NORMAL HUMAN-SUBJECTS [J].
BISIACCHI, P ;
MARZI, CA ;
NICOLETTI, R ;
CARENA, G ;
MUCIGNAT, C ;
TOMAIUOLO, F .
BEHAVIOURAL BRAIN RESEARCH, 1994, 64 (1-2) :173-178
[10]   FUNCTIONAL CONNECTIVITY IN THE MOTOR CORTEX OF RESTING HUMAN BRAIN USING ECHO-PLANAR MRI [J].
BISWAL, B ;
YETKIN, FZ ;
HAUGHTON, VM ;
HYDE, JS .
MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (04) :537-541