Boundary formation and maintenance in tissue development

被引:258
作者
Dahmann, Christian [1 ,2 ,3 ,4 ]
Oates, Andrew C. [3 ]
Brand, Michael [1 ,2 ]
机构
[1] Tech Univ Dresden, Ctr Biotechnol, BIOTEC, D-01307 Dresden, Germany
[2] Tech Univ Dresden, Ctr Regenerat Therapies CRTD, D-01307 Dresden, Germany
[3] Max Planck Inst Mol Cell Biol & Genet MPI CBG, D-01307 Dresden, Germany
[4] Tech Univ Dresden, Inst Genet, D-01217 Dresden, Germany
基金
欧洲研究理事会;
关键词
CHICK-EMBRYO HINDBRAIN; DORSOVENTRAL LINEAGE RESTRICTION; PRESOMITIC MESODERM; COMPARTMENT BOUNDARY; SOMITE-SEGMENTATION; CELL-ADHESION; LIMB BUD; DROSOPHILA-MELANOGASTER; MORPHOLOGICAL BOUNDARY; EPITHELIAL TRANSITION;
D O I
10.1038/nrg2902
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The formation and maintenance of boundaries between neighbouring groups of embryonic cells is vital for development because groups of cells with distinct functions must often be kept physically separated. Furthermore, because cells at the boundary often take on important signalling functions by acting as organizing centres, boundary shape and integrity can also control the outcome of many downstream patterning events. Recent experimental findings and theoretical descriptions have shed new light on classic questions about boundaries. In particular, in the past couple of years the role of forces acting in epithelial tissues to maintain boundaries has emerged as a new principle in understanding how early pattern is made into permanent anatomy.
引用
收藏
页码:43 / 55
页数:13
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