Effects of new generation triptans - frovatriptan and almotriptan - on hemodynamic parameters in intact male and female rats

被引:1
作者
Saracheva, Kremena [1 ]
Hrischev, Petar [1 ]
Vasileva, Liliya [1 ]
Topolov, Mariyan [1 ]
Nikolova, Julia [2 ]
Getova, Damianka [3 ]
机构
[1] Med Univ Plovdiv, Fac Pharm, Dept Pharmacol & Drug Toxicol, Plovdiv, Bulgaria
[2] Med Univ Plovdiv, Fac Med, Dept Physiol, Plovdiv, Bulgaria
[3] Technol Ctr Emergency Med TCEMED, Lab Neuropharmacol, Plovdiv, Bulgaria
关键词
almotriptan; frovatriptan; rat; arterial pressure; 5-HT7; RECEPTOR; SEROTONIN;
D O I
10.2478/acph-2020-0005
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses not only the typical 5-HT1B/1D receptor agonist activity, but shows an affinity to the 5-HT1F receptor. The aim of our study was to assess the impact of frovatriptan and almotriptan on hemodynamics in male and female rats. We used a non-invasive "tail-cuff" method to measure the arterial blood pressure. Female and male Wistar rats were treated separately with high and low dosages of frovatriptan and almotriptan. Male and female rats showed reduction in all hemodynamic parameters, but only male rats showed an increase in the heart rate. In general, we could say that both almotriptan and frovatriptan potentiate cardiovascular safety.
引用
收藏
页码:239 / 247
页数:9
相关论文
共 50 条
  • [31] The Effects of High Peripubertal Caffeine Exposure on the Adrenal Gland in Immature Male and Female Rats
    Ryu, Ki-Young
    Roh, Jaesook
    [J]. NUTRIENTS, 2019, 11 (05):
  • [32] Effects of chronic valproate treatment on reproductive endocrine hormones in female and male Wistar rats
    Roste, LS
    Tauboll, E
    Isojärvi, JIT
    Pakarinen, AJ
    Huhtaniemi, PT
    Knip, M
    Gjerstad, L
    [J]. REPRODUCTIVE TOXICOLOGY, 2002, 16 (06) : 767 - 773
  • [33] Differential effects of undernourishment and nutritional rehabilitation on serum leptin levels in male and female rats
    Pinos, Helena
    Ortega, Esperanza
    Carrillo, Beatriz
    Angeles Perez-Izquierdo, Mari
    Collado, Paloma
    [J]. NEUROCHEMICAL RESEARCH, 2007, 32 (03) : 407 - 413
  • [34] The effects of chronic corticosterone on hippocampal astrocyte numbers:: A comparison of male and female Wistar rats
    Bridges, Nikola
    Slais, Karel
    Sykova, Eva
    [J]. ACTA NEUROBIOLOGIAE EXPERIMENTALIS, 2008, 68 (02) : 131 - 138
  • [35] Differential Effects of Undernourishment and Nutritional Rehabilitation on Serum Leptin Levels in Male and Female Rats
    Helena Pinos
    Esperanza Ortega
    Beatriz Carrillo
    Mari Ángeles Pérez-Izquierdo
    Paloma Collado
    [J]. Neurochemical Research, 2007, 32 : 407 - 413
  • [36] SEX-DIFFERENCES AND THE EFFECTS OF ALCOHOL ON IMMUNE-RESPONSE IN MALE AND FEMALE RATS
    GROSSMAN, CJ
    NIENABER, M
    MENDENHALL, CL
    HURTUBISE, P
    ROSELLE, GA
    ROUSTER, S
    WEBER, N
    SCHMITT, G
    GARTSIDE, PS
    [J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1993, 17 (04) : 832 - 840
  • [37] Effects of aromatase inhibitors letrozole and anastrazole on bone metabolism and steroid hormone levels in intact female rats
    Kumru, Selahattin
    Yildiz, Azer A.
    Yilmaz, Bayram
    Sandal, Suleyman
    Gurates, Bilgin
    [J]. GYNECOLOGICAL ENDOCRINOLOGY, 2007, 23 (10) : 556 - 561
  • [38] The effects of prenatal androgen exposure on cardiac function and tolerance to ischemia/reperfusion injury in male and female rats during adulthood
    Noroozzadeh, Mahsa
    Raoufy, Mohammad Reza
    Yarandi, Razieh Bidhendi
    Shahrivar, Farzaneh Faraji
    Tehrani, Fahimeh Ramezani
    [J]. LIFE SCIENCES, 2019, 229 : 251 - 260
  • [39] Beneficial Effects of Quercetin on Sperm Parameters in Streptozotocin-Induced Diabetic Male Rats
    Khaki, Arash
    Fathiazad, Fatemeh
    Nouri, Mohammad
    Khaki, AmirAfshin
    Maleki, Navid A.
    Khamnei, Hossein Jabbari
    Ahmadi, Porya
    [J]. PHYTOTHERAPY RESEARCH, 2010, 24 (09) : 1285 - 1291
  • [40] The effects of Permethrin and antioxidant properties of Allium cepa (onion) on testicles parameters of male rats
    Khaki, Arash
    Khaki, Amir Afshin
    Rajabzadeh, Asghar
    [J]. TOXIN REVIEWS, 2017, 36 (01) : 1 - 6