Effects of trifluoperazine on the conformation and dynamics of membrane proteins in human erythrocytes

被引：3
|
作者：
Ruggiero, AC [1 ]
Meirelles, NC
机构：
[1] UNICAMP, Inst Biol, Dept Bioquim, BR-13801 Campinas, SP, Brazil
[2] UNIMEP, Ctr Ciencias Exatas, Dept Quim, BR-13400901 Piracicaba, SP, Brazil
来源：
MOLECULAR GENETICS AND METABOLISM | 1998年 / 64卷 / 02期
关键词：
trifluoperazine; erythrocyte membrane; fluorescence;
D O I：
10.1006/mgme.1998.2689
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The chemical modifications induced by trifluoperazine (TFP) in erythrocyte ghosts have been investigated by fluorescence quenching. The apparent distance separating the membrane protein tryptophans and bound 1-aniline-8-naphthalene sulfonate (ANS) molecules decreased after treating erythrocyte membranes with TFP. This effect was accompanied by a significant decrease in the maximum efficiency of energy transfer. We conclude that TFP-induced alterations in the structure of membrane proteins lead to a rearrangement of the surrounding lipids, and consequently to local conformational changes in membrane organization. (C) 1998 Academic Press.
引用
收藏
页码：148 / 151
页数：4
相关论文
共 50 条
  • [21] Deoxygenation Affects Composition of Membrane-Bound Proteins in Human Erythrocytes
    Luneva, Oksana G.
    Sidorenko, Svetlana V.
    Ponomarchuk, Olga O.
    Tverskoy, Artem M.
    Cherkashin, Aleksander A.
    Rodnenkov, Oleg V.
    Alekseeva, Natalia V.
    Deev, Leonid I.
    Maksimov, Georgy V.
    Grygorczyk, Ryszard
    Orlov, Sergei N.
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2016, 39 (01) : 81 - 88
  • [22] GLYCOPHOSPHOLIPID-LINKED MEMBRANE-PROTEINS OF HUMAN-ERYTHROCYTES
    SUGITA, Y
    SEIKAGAKU, 1988, 60 (06): : 441 - 445
  • [23] PHOSPHORYLATION-DEPHOSPHORYLATION OF MEMBRANE-PROTEINS OF HUMAN-ERYTHROCYTES
    MORET, V
    ITALIAN JOURNAL OF BIOCHEMISTRY, 1984, 33 (04): : A233 - A237
  • [24] MEMBRANE-PROTEINS IN SENESCENT ERYTHROCYTES
    SUZUKI, T
    DALE, GL
    BIOCHEMICAL JOURNAL, 1989, 257 (01) : 37 - 41
  • [25] EFFECTS OF TRIFLUOPERAZINE AND MEMBRANE-BOUND SIALIC-ACID ON CA-45(2+) UPTAKE INTO ERYTHROCYTES
    GUNTHER, T
    HOLLRIEGL, V
    FEHLINGER, R
    JOURNAL OF TRACE ELEMENTS AND ELECTROLYTES IN HEALTH AND DISEASE, 1988, 2 (01): : 15 - 18
  • [26] EFFECTS OF TRIFLUOPERAZINE ON HUMAN NEUTROPHIL FUNCTION
    SMITH, RJ
    BOWMAN, BJ
    IDEN, SS
    IMMUNOLOGY, 1981, 44 (04) : 677 - 684
  • [27] MEMBRANE PROTEINS IN HUMAN ERYTHROCYTES DURING CELL-FUSION INDUCED BY OLEOYLGLYCEROL
    QUIRK, SJ
    AHKONG, QF
    BOTHAM, GM
    VOS, J
    LUCY, JA
    BIOCHEMICAL JOURNAL, 1978, 176 (01) : 159 - &
  • [28] In vitro incorporation of GPI-anchored proteins into human erythrocytes and their fate in the membrane
    Civenni, G
    Test, ST
    Brodbeck, U
    Bütikofer, P
    BLOOD, 1998, 91 (05) : 1784 - 1792
  • [29] Mechanism of selective release of membrane proteins from human erythrocytes in the presence of liposomes
    Suzuki, K
    Okumura, Y
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2000, 379 (02) : 344 - 352
  • [30] DISTRIBUTION RELATED EFFECTS OF CHLOROTETRACYCLINE IN THE MEMBRANE OF HUMAN-ERYTHROCYTES
    MONTALAR, Y
    BONILLA, S
    BEHN, C
    ARCHIVOS DE BIOLOGIA Y MEDICINA EXPERIMENTALES, 1987, 20 (02): : R223 - R223
12345