Aquaporins and Their Regulation after Spinal Cord Injury

被引：29
|
作者：
Halsey, Andrea M. [1 ]
Conner, Alex C. [2 ]
Bill, Roslyn M. [3 ]
Logan, Ann [1 ]
Ahmed, Zubair [1 ]
机构：
[1] Univ Birmingham, Neurosci & Ophthalmol, Inst Inflammat & Ageing, Birmingham B15 2TT, W Midlands, England
[2] Univ Birmingham, Inst Clin Sci, Birmingham B15 2TT, W Midlands, England
[3] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England
来源：
CELLS | 2018年 / 7卷 / 10期
关键词：
spinal cord injury; edema; aquaporin; water channel; X-RAY-STRUCTURE; CELL-VOLUME REGULATION; HEALTH-CARE COSTS; WATER CHANNEL; CHOROID-PLEXUS; STRUCTURAL DETERMINANTS; INTRACRANIAL-PRESSURE; MOLECULAR-MECHANISMS; CEREBROSPINAL-FLUID; PLASMA-MEMBRANES;
D O I：
10.3390/cells7100174
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
After injury to the spinal cord, edema contributes to the underlying detrimental pathophysiological outcomes that lead to worsening of function. Several related membrane proteins called aquaporins (AQPs) regulate water movement in fluid transporting tissues including the spinal cord. Within the cord, AQP1, 4 and 9 contribute to spinal cord injury (SCI)-induced edema. AQP1, 4 and 9 are expressed in a variety of cells including astrocytes, neurons, ependymal cells, and endothelial cells. This review discusses some of the recent findings of the involvement of AQP in SCI and highlights the need for further study of these proteins to develop effective therapies to counteract the negative effects of SCI-induced edema.
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页数：22
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