New tirucallane-type triterpenes from Dysoxylum variabile

被引：38
|
作者：
Liu, HM
Heilmann, J
Rali, T
Sticher, O [1 ]
机构：
[1] Univ Zurich, Swiss Fed Inst Technol, Inst Pharmaceut Sci, Dept Appl Biosci, CH-8057 Zurich, Switzerland
[2] PNG Biodivers PTY Ltd, Port Moresby, Papua N Guinea
来源：
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 02期
关键词：
D O I：
10.1021/np0002841
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eight new tirucallane-type triterpenes, dyvariabilins A-H (1-8), three known tirucallanes, niloticin (9), dihydroniloticin (10), and tirucalla-7,24-diene-3 beta ,23-diol (11), and two known sesquiterpenes, 1-(1-hydroxy-2-methylpropyl)-3a-methyl-7-methyleneoetahydroinden-4-ol and (+)-aphanamol I, were isolated from the stem bark of Dysoxylum variabile. Tirucallanes 1 and 11 with an allylic hydroxy group in the side chain and dyvariabilin C (3) with an alpha -epoxy group at positions 7 and 8 showed high instabilty in acidic medium and formed five hitherto unknown semisynthetic tirucallanes. Dyvariabilins B (2) and C (3) as well as the mixtures of dyvariabilins E and F (5 and (6) and dyvariabilins G and H (7 and 8) showed weak cytotoxicity against KB cells.
引用
收藏
页码：159 / 163
页数：5
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