Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study

被引：14

作者：

Rangaraj, Vittobai Rashika ^{[1
]}

Siddula, Alankrita ^{[2
]}

Burgess, Helen J. ^{[3
]}

Pannain, Silvana ^{[1
]}

Knutson, Kristen L. ^{[2
]}

机构：

[1] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[2] Northwestern Univ, Feinberg Sch Med, Ctr Circadian & Sleep Med, Dept Neurol, Chicago, IL 60611 USA

[3] Univ Michigan, Dept Psychiat, Sleep & Circadian Res Lab, Ann Arbor, MI 48109 USA

来源：

NUTRIENTS | 2020年 / 12卷 / 02期

基金：

美国国家卫生研究院;

关键词：

circadian rhythm; insulin resistance; diet habits; Type; 2; Diabetes; TYPE-2 DIABETES RISK; ROTATING SHIFT-WORK; METABOLIC SYNDROME; FOOD-INTAKE; BREAKFAST FREQUENCY; EATING PATTERNS; WEIGHT-LOSS; RESISTANCE; INDEXES; OVERWEIGHT;

D O I：

10.3390/nu12020503

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

In addition to the caloric and macronutrient composition of meals, timing of energy consumption may be important for optimal glucose metabolism. Our goal was to examine whether the habitual timing of energy intake was associated with insulin sensitivity in healthy volunteers. Volunteers without diabetes aged 21-50 years completed a 3-day food diary and underwent an oral glucose tolerance test to estimate insulin sensitivity (n = 44). From the food diary, we calculated the proportions of the total energy and macronutrients consumed in the morning and evening, and the clock time at which 25%, 50% and 75% of total energy was consumed. A greater proportion of energy intake in the morning was significantly associated with higher insulin sensitivity estimated by Matsuda Index (B = 2.8 per 10%; 95%CI: 0.3, 5.2). The time at which 25% of energy was consumed was associated with insulin sensitivity estimated by Matsuda Index (B = 1.6 per hour; 95%CI: 3.0, 0.3) and QUICKI (B = 1.4 per hour, 95%CI: 2.8, 0.1). The timing of carbohydrate consumption demonstrated similar associations. Greater energy intake earlier in the day was associated with higher insulin sensitivity in individuals without diabetes.

引用

页数：13