Does Eryngium maritimum seeds extract protect against CCl4 and cisplatin induced toxicity in rats: Preliminary phytochemical screening and assessment of its in vitro and in vivo antioxidant activity and: antifibrotic effect

被引：19

作者：

Mejri, Houda ^{[1
]}

Tir, Meriam ^{[2
]}

Feriani, Anouar ^{[3
,4
]}

Ghazouani, Lakhdhar ^{[3
]}

Allagui, Mohamed Salah ^{[4
]}

Saidani-Tounsi, Moufida ^{[1
]}

机构：

[1] Ctr Biotechnol Borj Cedria, Lab Plantes Aromat & Med, Hammam Lif, Tunisia

[2] Univ Tunis EL Manar, Fac Sci Tunis, UR Physiol & Environm Aquat, Tunis 2092, Tunisia

[3] Univ Gafsa, Unite Biochim Macromol & Genet, Fac Sci Gafsa, Cite Zarroug, Gafsa 2112, Tunisia

[4] Fac Sci, Lab Ecophysiol Anim, Sfax 3018, Tunisia

来源：

JOURNAL OF FUNCTIONAL FOODS | 2017年 / 37卷

关键词：

Eryngium maritimum; Phytochemical; Antioxidant; Hepatoprotective; Nephroptotective; Antifibrotic; OXIDATIVE STRESS; INDUCED NEPHROTOXICITY; FOLK MEDICINE; LIVER-INJURY; FIBROSIS; INFLAMMATION; MECHANISMS; LEAVES; DAMAGE; ACIDS;

D O I：

10.1016/j.jff.2017.07.054

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The present work was undertaken to investigate the protective effects of Eryngium maritimum seeds extract (MEE) against CCl4 and cisplatin induced toxicity in rats. The levels of total phenolics and flavonoids were ca. 20 mg GAE/g and ca. 19 mg QE/g, respectively. Using HPLC twenty-one molecules were identified. MEE showed important in vitro antioxidant activities. Results demonstrated that MEEtreatment restored the increased activities of AST, ALT, LDH and ALP and the high levels of serum creatinine, urea and uric acid levels induced by CCl4 and cisplatin treatment. Moreover, MEE presented important in vivo antioxidant activities; increased the activities of CAT, SOD and GPx and decreased the TBARS and protein carbonyl contents. The histopathological studies suggested that MEE clearly alleviated the degree of tissues fibrosis. The obtained results highlighted the potential use of E. maritimum as a source of bioactive compounds with hepatoprotective and nephroprotective advantages. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：363 / 372

页数：10