Constituents of the stem barks of Ailanthus altissima and their potential to inhibit LPS-induced nitric oxide production

被引：38

作者：

Kim, Hye Mi ^{[1
]}

Kim, Su Jung ^{[1
]}

Kim, Ha-Yeong ^{[2
]}

Ryu, Byeol ^{[2
]}

Kwak, Hokwang ^{[2
]}

Hur, Jonghyun ^{[3
]}

Choi, Jung-Hye ^{[1
,2
]}

Jang, Dae Sik ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea

[2] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea

[3] Whan In Pharm Co Ltd, Cent Res Inst, Suwon 443766, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Ailanthus altissima; Simaroubaceae; Canthinone type alkaloids; Nitric oxide; Inflammation; MILL; SWINGLE; LEAVES; SEEDS;

D O I：

10.1016/j.bmcl.2015.01.034

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new canthinone type alkaloids, canthin-6-one-1-O-beta-D-apiofuranosyl-(1 -> 2)-beta-D-glucopyranoside (1), canthin-6-one-1-O-[6-O-(3-hydroxy-3-methylglutaryl)]-beta-D-glucopyranoside (2) and canthin-6-one-1-O-[2-beta-D-apiofuranosyl-6-O-(3-hydroxy-3-methylglutaryl)]-beta-D-glucopyranoside (3) were isolated from the stem barks of Ailanthus altissima together with four quassinoids (4-7), seven phenylpropanoids (8-14) and a lignan of previously known structure (15). The inflammatory activities of the 15 isolates were screened on LPS-induced nitric oxide (NO), a proinflammatory mediator, in RAW 264.7 cells. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：1017 / 1020

页数：4

共 17 条

[1] Phytochemicals, antioxidant, antimicrobial and phytotoxic activities of Ailanthus altissima (Mill.) Swingle leaves
Albouchi, Ferdaous
Hassen, Imed
Casabianca, Herve
Hosni, Karim
[J]. SOUTH AFRICAN JOURNAL OF BOTANY, 2013, 87 : 164 - 174
[2] New macrocyclic diamide from Rauvolfia yunnanensis Tsiang
Geng Chang-an
Liu Xi-kui
[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2008, 24 (03) : 303 - 305
[3] Hwang SW, 2005, HETEROCYCLES, V65, P1963
[4] Jones L., 2000, Fitoterapia, V71, P580, DOI 10.1016/S0367-326X(00)00155-6
[5] Biological flora of Central Europe:: Ailanthus altissima (Mill.) Swingle
Kowarik, Ingo
Saeumel, Ina
[J]. PERSPECTIVES IN PLANT ECOLOGY EVOLUTION AND SYSTEMATICS, 2007, 8 (04) : 207 - 237
[6] Two new quassinoids, ailantinols A and B, and related compounds from Ailanthus altissima
Kubota, K
Fukamiya, N
Hamada, T
Okano, M
Tagahara, K
Lee, KH
[J]. JOURNAL OF NATURAL PRODUCTS, 1996, 59 (07): : 683 - 686
[7] A brief resume on the genus Ailanthus: chemical and pharmacological aspects
Kundu, Pijush
Laskar, Subrata
[J]. PHYTOCHEMISTRY REVIEWS, 2010, 9 (03) : 379 - 412
[8] Isolation of Phenylpropanoid Glucosides from Sesame Seeds
Lee, Sun Hee
Kim, Kwan Su
Bu, Young Min
Park, Si Hyung
[J]. JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, 2009, 52 (01): : 102 - 104
[9] OHMOTO T, 1984, CHEM PHARM BULL, V32, P170
[10] Pavela R, 2014, PAK J AGR SCI, V51, P101

← 1 2 →