Possible activation of effector B cells during drug-induced hypersensitivity syndrome

被引：1

作者：

Matsumura, Yutaka ^{[1
,2
]}

Watanabe, Rei ^{[1
,2
]}

Niijima, Yasuko ^{[1
]}

Kawakita, Haruka ^{[1
]}

Furuta, Junichi ^{[1
]}

Nakamura, Yoshiyuki ^{[1
]}

Ishitsuka, Yosuke ^{[1
,2
]}

Okiyama, Naoko ^{[1
]}

Fujisawa, Yasuhiro ^{[1
]}

Fujimoto, Manabu ^{[1
,2
]}

机构：

[1] Univ Tsukuba, Dept Dermatol, Ibaraki, Japan

[2] Osaka Univ, Grad Sch Med, Dept Dermatol, Course Integrated Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY | 2021年 / 4卷 / 06期

关键词：

APRIL; B cells; BAFF; cytokines; drug-induced hypersensitivity syndrome; REGULATORY T-CELLS; BAFF; IL-6; INTERLEUKIN-10; EOSINOPHILIA; APRIL;

D O I：

10.1002/cia2.12191

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Although the development of autoimmune disorders is recognized in drug-induced hypersensitivity syndrome (DIHS), the serial change of B-cell activity has not been well-addressed. Herein, the serum levels of IL-6, IL-10, B-cell activating factor of the tumor necrosis factor family (BAFF), and a proliferation-inducing ligand (APRIL) in three DIHS patients were tracked over time. While IL-6 and IL-10 tended to be elevated according to the disease activity, BAFF and APRIL increased during the improved phase. Our results imply that the continuous activation of B cells may be involved in the prolonged disease activity of DIHS and the development of autoimmune disorders.

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收藏

页码：166 / 169

页数：4

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