Caffeic Acid Esters and Lignans from Piper sanguineispicum

被引：40

作者：

Cabanillas, Billy Joel ^{[1
,3
]}

Le Lamer, Anne-Cecile ^{[1
]}

Castillo, Denis ^{[2
]}

Arevalo, Jorge ^{[2
]}

Rojas, Rosario ^{[2
]}

Odonne, Guillaume ^{[1
]}

Bourdy, Genevieve ^{[1
,3
]}

Moukarzel, Beatrice ^{[1
]}

Sauvain, Michel ^{[1
,3
]}

Fabre, Nicolas ^{[1
]}

机构：

[1] Univ Toulouse, UPS, UMR 152, Lab Pharmacochim Subst Nat & Pharmacophores Redox, F-31062 Toulouse 9, France

[2] Univ Peruana Cayetano Heredia, Lab Invest & Desarrollo, Fac Ciencias & Filosofia, Lima, Peru

[3] Mission IRD, UMR 152, Lima, Peru

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 11期

关键词：

LEISHMANICIDAL ACTIVITY; ABSOLUTE-CONFIGURATION; CHEMICAL-CONSTITUENTS; IN-VITRO; PLANTS; STEREOCHEMISTRY; CHEMOTHERAPY; AMAZONENSIS;

D O I：

10.1021/np1005357

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new caffeic acid esters (1-3), four new lignans (4-7), and the known compounds (7'S)-parabenzlactone (8), dihydrocubebin (9), and justiflorinol (10) have been isolated from leaves of Piper sanguineispicum. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRCIMS, CD experiments, and chemical methods. Compounds 1-10 were assessed for their antileishmanial potential against axenic amastigote forms of Leishmania amazonensis. Caffeic acid esters 1 and 3 exhibited the best antileishmanial activity (IC50 2.0 and 1.8 mu M, respectively) with moderate cytotoxicity on murine macrophages.

引用

页码：1884 / 1890

页数：7

共 29 条

[1] [Anonymous], 2007, 5 CONS M LEISHM HIV
[2] Coumarins from Galipea panamensis and Their Activity against Leishmania panamensis
Arango, Victor
Robledo, Sara
Seon-Meniel, Blandine
Figadere, Bruno
Cardona, Wilson
Saez, Jairo
Otalvaro, Felipe
[J]. JOURNAL OF NATURAL PRODUCTS, 2010, 73 (05): : 1012 - 1014
[3] Spirolactone iridoids might be responsible for the antileishmanial activity of a Peruvian traditional remedy made with Himatanthus sucuuba (Apocynaceae)
Castillo, D.
Arevalo, J.
Herrera, F.
Ruiz, C.
Rojas, R.
Rengifo, E.
Vaisberg, A.
Lock, O.
Lemesre, J.-L.
Gornitzka, H.
Sauvain, M.
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2007, 112 (02) : 410 - 414
[4] Plant natural products with leishmanicidal activity
Chan-Bacab, MJ
Peña-Rodríguez, LM
[J]. NATURAL PRODUCT REPORTS, 2001, 18 (06) : 674 - 688
[5] CHEMICAL CONSTITUENTS OF AUSTRALIAN ZANTHOXYLUM SPECIES .5. CONSTITUENTS OF Z-PLUVIATILE HARTLEY . STRUCTURES OF 2 NEW LIGNANS
CORRIE, JET
GREEN, GH
RITCHIE, E
TAYLOR, WC
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1970, 23 (01) : 133 - &
[6] Chemotherapy of trypanosomiases and leishmaniasis
Croft, SL
Barrett, MP
Urbina, JA
[J]. TRENDS IN PARASITOLOGY, 2005, 21 (11) : 508 - 512
[7] Davies C R, 2000, Cad Saude Publica, V16, P925, DOI 10.1590/S0102-311X2000000400013
[8] DE CARVALHO MG, 1987, PHYTOCHEMISTRY, V26, P265
[9] Evaluation of the leishmanicidal activity of plants used by Peruvian Chayahuita ethnic group
Estevez, Y.
Castillo, D.
Pisango, M. Tangoa
Arevalo, J.
Rojas, R.
Alban, J.
Deharo, E.
Bourdy, G.
Sauvain, M.
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2007, 114 (02) : 254 - 259
[10] Leishmanicidal constituents from the leaves of Piper rusbyi
Flores, Ninoska
Cabrera, Gabriela
Jimenez, Ignacio A.
Pinero, Jose
Gimenez, Alberto
Bourdy, Genevieve
Cortes-Selva, Fernando
Bazzocchi, Isabel L.
[J]. PLANTA MEDICA, 2007, 73 (03) : 206 - 211

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