Role of IL-6 in the commitment of T cell subsets

被引:76
作者
Korn, Thomas [1 ,2 ,3 ]
Hiltensperger, Michael [1 ]
机构
[1] Tech Univ Munich, Klinikum Rechts Isar, Inst Expt Neuroimmunol, Ismaninger Str 22, D-81675 Munich, Germany
[2] Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, Ismaninger Str 2, D-81675 Munich, Germany
[3] Munich Cluster Syst Neurol SyNergy, Feodor Lynen Str 17, D-81377 Munich, Germany
关键词
IL-6; Th17; cell; T follicular helper cell; Treg cell; IL-6 cluster signaling; Host defence; Autoimmunity; SOLUBLE INTERLEUKIN-6 RECEPTOR; NEUROMYELITIS-OPTICA; TGF-BETA; T(H)17 CELLS; TH17; CELLS; GENERATION; PLASTICITY; RESPONSES; CYTOKINE; DIFFERENTIATION;
D O I
10.1016/j.cyto.2021.155654
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
IL-6 gained much attention with the discovery that this cytokine is a non-redundant differentiation factor for Th17 cells and T follicular helper cells. Adaptive immune responses to fungi and extracellular bacteria are impaired in the absence of IL-6. IL-6 is also required for the induction of ROR-gamma t+ Treg cells, which are gatekeepers of homeostasis in the gut lamina propria in the presence of commensal bacteria. Conversely, severe immunopathology in T cell-mediated autoimmunity is mediated by Th17 cells that rely on IL-6 for their generation and maintenance. Recently, it has been discovered that the differentiation of these distinct T helper cell subsets may be linked to distinct signaling modalities of IL-6. Here, we summarize the current knowledge on the mode of action of IL-6 in the differentiation and maintenance of T cell subsets and propose that a contextdependent understanding of the impact of IL-6 on T cell subsets might inform rational IL-6-directed interventions in autoimmunity and chronic inflammation.
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页数:8
相关论文
共 106 条
  • [1] Acharya D, 2017, J VIROL, V91, DOI [10.1128/JVI.01529-16, 10.1128/jvi.01529-16]
  • [2] Progressive Multifocal Leukoencephalopathy during Tocilizumab Treatment for Rheumatoid Arthritis
    Anada, Mamiko
    Tohyama, Miyoka
    Oda, Yoshitaka
    Kamoshima, Yuuta
    Amino, Itaru
    Nakano, Fumihito
    Miyazaki, Yusei
    Akimoto, Sachiko
    Minami, Naoya
    Kikuchi, Seiji
    Terae, Satoshi
    Niino, Masaaki
    [J]. INTERNAL MEDICINE, 2020, 59 (16) : 2053 - 2059
  • [3] Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation:: Evidence in Crohn disease and experimental colitis in vivo
    Atreya, R
    Mudter, J
    Finotto, S
    Müllberg, J
    Jostock, T
    Wirtz, S
    Schütz, M
    Bartsch, B
    Holtmann, M
    Becker, C
    Strand, D
    Czaja, J
    Schlaak, JF
    Lehr, HA
    Autschbach, F
    Schürmann, G
    Nishimoto, N
    Yoshizaki, K
    Ito, H
    Kishimoto, T
    Galle, PR
    Rose-John, S
    Neurath, MF
    [J]. NATURE MEDICINE, 2000, 6 (05) : 583 - 588
  • [4] Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans
    Bacher, Petra
    Hohnstein, Thordis
    Beerbaum, Eva
    Roecker, Marie
    Blango, Matthew G.
    Kaufmann, Svenja
    Roehmel, Jobst
    Eschenhagen, Patience
    Grehn, Claudia
    Seidel, Kathrin
    Rickerts, Volker
    Lozza, Laura
    Stervbo, Ulrik
    Nienen, Mikalai
    Babel, Nina
    Milleck, Julia
    Assenmacher, Mario
    Cornely, Oliver A.
    Ziegler, Maren
    Wisplinghoff, Hilmar
    Heine, Guido
    Worm, Margitta
    Siegmund, Britta
    Maul, Jochen
    Creutz, Petra
    Tabeling, Christoph
    Ruwwe-Gloesenkamp, Christoph
    Sander, Leif E.
    Knosalla, Christoph
    Brunke, Sascha
    Hube, Bernhard
    Kniemeyer, Olaf
    Brakhage, Axel A.
    Schwarz, Carsten
    Scheffold, Alexander
    [J]. CELL, 2019, 176 (06) : 1340 - +
  • [5] MS arising during Tocilizumab therapy for rheumatoid arthritis
    Beauchemin, Philippe
    Carruthers, Robert
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2016, 22 (02) : 254 - 256
  • [6] Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    Bettelli, E
    Carrier, YJ
    Gao, WD
    Korn, T
    Strom, TB
    Oukka, M
    Weiner, HL
    Kuchroo, VK
    [J]. NATURE, 2006, 441 (7090) : 235 - 238
  • [7] IL-6 signaling in macrophages is required for immunotherapy-driven regression of tumors
    Beyranvand Nejad, Elham
    Labrie, Camilla
    van Elsas, Marit J.
    Kleinovink, Jan Willem
    Mittrucker, Hans-Willi
    Franken, Kees L. M. C.
    Heink, Sylvia
    Korn, Thomas
    Arens, Ramon
    van Hall, Thorbald
    van der Burg, Sjoerd H.
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 (04)
  • [8] Cutting edge: Soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells
    Briso, Eva M.
    Dienz, Oliver
    Rincon, Mercedes
    [J]. JOURNAL OF IMMUNOLOGY, 2008, 180 (11) : 7102 - 7106
  • [9] Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis
    Brucklacher-Waldert, Verena
    Sturner, Klarissa
    Kolster, Manuela
    Wolthausen, Julia
    Tolosa, Eva
    [J]. BRAIN, 2009, 132 : 3329 - 3341
  • [10] Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis
    Cao, Yonghao
    Goods, Brittany A.
    Raddassi, Khadir
    Nepom, Gerald T.
    Kwok, William W.
    Love, J. Christopher
    Hafler, David A.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (287)