Polymers for Drug Delivery Systems

被引:1088
|
作者
Liechty, William B. [1 ]
Kryscio, David R. [1 ]
Slaughter, Brandon V. [2 ]
Peppas, Nicholas A. [1 ,2 ,3 ]
机构
[1] Univ Texas Austin, Dept Chem Engn, Austin, TX 78712 USA
[2] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA
[3] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA
来源
ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, VOL 1 | 2010年 / 1卷
基金
美国国家科学基金会;
关键词
controlled release; stimuli-responsive; responsive polymers; recognitive polymers; polymer therapeutics; intracellular delivery; SOFT CONTACT-LENSES; POLY(BETA-AMINO ESTER) NANOPARTICLES; MEMBRANE-DISRUPTIVE ACTIVITY; TUMOR-TARGETED DELIVERY; PH-RESPONSIVE POLYMERS; IN-VITRO; HPMA COPOLYMER; CORE/SHELL NANOPARTICLES; SENSITIVE HYDROGELS; COVALENT ATTACHMENT;
D O I
10.1146/annurev-chembioeng-073009-100847
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs. From early beginnings using off-the-shelf materials, the field has grown tremendously, driven in part by the innovations of chemical engineers. Modern advances in drug delivery are now predicated upon the rational design of polymers tailored for specific cargo and engineered to exert distinct biological functions. In this review, we highlight the fundamental drug delivery systems and their mathematical foundations and discuss the physiological barriers to drug delivery. We review the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The latest developments in polymers capable of molecular recognition or directing intracellular delivery are surveyed to illustrate areas of research advancing the frontiers of drug delivery.
引用
收藏
页码:149 / 173
页数:25
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