Mechanisms of PTEN loss in cancer: It's all about diversity

被引：310

作者：

Alvarez-Garcia, Virginia ^{[1
,2
]}

Tawil, Yasmine ^{[1
]}

Wise, Helen M. ^{[1
]}

Leslie, Nicholas R. ^{[1
]}

机构：

[1] Heriot Watt Univ, Inst Biol Chem Biophys & Bioengn, Edinburgh EH14 4AS, Midlothian, Scotland

[2] Univ Edinburgh, Western Gen Hosp, Canc Res UK Edinburgh Ctr, Edinburgh EH4 2XR, Midlothian, Scotland

来源：

SEMINARS IN CANCER BIOLOGY | 2019年 / 59卷

关键词：

Cancer; Tumour suppressor; PTEN; PI; 3-Kinase; Mutation; CELL LUNG-CANCER; TUMOR-SUPPRESSOR PTEN; EPITHELIAL-MESENCHYMAL TRANSITION; GROWTH-FACTOR RECEPTOR; TENSIN-HOMOLOG PTEN; OVARIAN-CANCER; COLORECTAL-CANCER; PROSTATE-CANCER; MICRORNA EXPRESSION; UBIQUITIN LIGASE;

D O I：

10.1016/j.semcancer.2019.02.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PTEN is a phosphatase which metabolises PIPS, the lipid product of PI 3-Kinase, directly opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly, loss of function of the PTEN tumour suppressor is one of the most common events observed in many types of cancer. Although the mechanisms by which PTEN function is disrupted are diverse, the most frequently observed events are deletion of a single gene copy of PTEN and gene silencing, usually observed in tumours with little or no PTEN protein detectable by immunohistochemistry. Accordingly, with the exceptions of glioblastoma and endometrial cancer, mutations of the PTEN coding sequence are uncommon ( < 10%) in most types of cancer. Here we review the data relating to PTEN loss in seven common tumour types and discuss mechanisms of PTEN regulation, some of which appear to contribute to reduced PTEN protein levels in cancers.

引用

页码：66 / 79

页数：14

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