A nano-fibrous assembly of collagen-hyaluronic acid for controlling cell-adhesive properties

被引:29
|
作者
Fujie, Toshinori [1 ]
Furutate, Sho [1 ]
Niwa, Daisuke [1 ]
Takeoka, Shinji [1 ,2 ]
机构
[1] Waseda Univ, Dept Life Sci & Med Biosci, Grad Sch Adv Sci & Engn, Shinjuku Ku, Tokyo 1628480, Japan
[2] Waseda Univ, High Tech Res Ctr, Tokyo 1628480, Japan
关键词
POLYELECTROLYTE MULTILAYERS; FILMS; DIFFERENTIATION; NANOSCALE; SUBSTRATE; STIFFNESS;
D O I
10.1039/c0sm00527d
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
We report an artificially fabricated extracellular matrix (ECM)-like nanostructure, which utilizes self-assembly of collagen and hyaluronic acid in a quasi two-dimensional space of tens-of-nm thickness, displaying different cellular adhesive characteristics depending on the structural properties between the fibril and non-fibril elements. This nano-fibrous assembly will facilitate a mechanobiological approach for the development of tissue-engineering scaffolds.
引用
收藏
页码:4672 / 4676
页数:5
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