共 12 条
A nano-fibrous assembly of collagen-hyaluronic acid for controlling cell-adhesive properties
被引:29
|作者:
Fujie, Toshinori
[1
]
Furutate, Sho
[1
]
Niwa, Daisuke
[1
]
Takeoka, Shinji
[1
,2
]
机构:
[1] Waseda Univ, Dept Life Sci & Med Biosci, Grad Sch Adv Sci & Engn, Shinjuku Ku, Tokyo 1628480, Japan
[2] Waseda Univ, High Tech Res Ctr, Tokyo 1628480, Japan
来源:
关键词:
POLYELECTROLYTE MULTILAYERS;
FILMS;
DIFFERENTIATION;
NANOSCALE;
SUBSTRATE;
STIFFNESS;
D O I:
10.1039/c0sm00527d
中图分类号:
O64 [物理化学(理论化学)、化学物理学];
学科分类号:
070304 ;
081704 ;
摘要:
We report an artificially fabricated extracellular matrix (ECM)-like nanostructure, which utilizes self-assembly of collagen and hyaluronic acid in a quasi two-dimensional space of tens-of-nm thickness, displaying different cellular adhesive characteristics depending on the structural properties between the fibril and non-fibril elements. This nano-fibrous assembly will facilitate a mechanobiological approach for the development of tissue-engineering scaffolds.
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页码:4672 / 4676
页数:5
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