Clinical utility of bone markers in various diseases

被引：48

作者：

Vlot, M. C. ^{[1
,2
]}

den Heijer, M. ^{[2
]}

de Jongh, R. T. ^{[2
]}

Vervloet, M. G. ^{[3
]}

Lems, W. F. ^{[4
]}

de Jonge, R. ^{[1
]}

Obermayer-Pietsch, B. ^{[5
]}

Heijboer, A. C. ^{[1
,6
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Endocrine Lab, Dept Clin Chem, de Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, Dept Internal Med, Endocrinol, de Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[3] Vrije Univ Amsterdam Med Ctr, Amsterdam Cardiovasc Sci, Dept Nephrol, de Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[4] Vrije Univ Amsterdam Med Ctr, Dept Rheumatol, de Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[5] Med Univ Graz, Dept Internal Med Endocrinol & Diabetol, A-8036 Graz, Austria

[6] Acad Med Ctr, Lab Endocrinol, Dept Clin Chem, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

来源：

BONE | 2018年 / 114卷

关键词：

Bone markers; Bone turnover; Review; Bone derived hormones; Clinical utility; Metabolic bone disease; Paget; Osteoporosis; Tumor induced osteomalacia; van Buchem disease; Hypophosphatemic disease; Osteoblast; Osteoclast; Osteocyte; FGF23; PINP; CTX-I; BALP; Osteocalcin; Sclerostin; GROWTH-FACTOR; 23; CHRONIC KIDNEY-DISEASE; KAPPA-B LIGAND; METASTATIC PROSTATE-CANCER; TUMOR-INDUCED OSTEOMALACIA; I COLLAGEN NTX; TURNOVER MARKERS; RHEUMATOID-ARTHRITIS; PAGETS-DISEASE; BIOCHEMICAL-MARKERS;

D O I：

10.1016/j.bone.2018.06.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Measurements of bone markers (BMs) in peripheral blood or urine are a pivotal part of bone research within modern clinical medicine. In recent years the use of BMs increased substantially as they can be useful either to diagnose bone (related) disease and to follow its natural history, but also to monitor the effects of interventions. However, the use of BMs is still complicated mainly due to (pre)analytical variability of these substances, limited accessibility of assays, variable cut-off values in different countries and laboratories and heterogeneous results with regard to clinical implications of measuring BMs in several studies. This review will provide the clinician with a practical guide, based on current evidence, in which circumstances to test which bone markers for optimal diagnostic purposes, in order to improve patient care in different areas of bone diseases including Paget's disease, primary osteoporosis, tumor induced osteomalacia, hypophosphatemic rickets, van Buchem disease, chronic kidney disease, rheumatoid arthritis, neoplasma/multiple myeloma, type 2 diabetes mellitus and primary hyperparathyroidism. The clinician should consider fasting state, recent fractures, aging, menopausal status, concomitant liver and kidney disease when ordering and interpreting BM measurements as these factors might result in misleading BM concentrations. We found that BMs are clearly useful in the current diagnosis of tumor induced osteomalacia, van Buchem disease, Paget's disease and hypophosphatemic rickets. In addition, BMs are useful to monitor disease activity in chronic kidney disease, Paget's disease and are useful to monitor treatment adherence in osteoporosis.

引用

页码：215 / 225

页数：11

共 189 条

[1] Validity of bone marker measurements for monitoring response to bisphosphonate therapy with zoledronic acid in metastatic breast cancer [J].